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3/30/2026 8:58:26 AM | Browse: 0 | Download: 0
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Received |
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2025-10-15 08:34 |
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Peer-Review Started |
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2025-10-15 08:34 |
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First Decision by Editorial Office Director |
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2025-11-05 06:31 |
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Return for Revision |
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2025-11-05 06:31 |
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Revised |
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2025-11-17 03:20 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-18 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-18 09:17 |
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Articles in Press |
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2025-12-18 09:17 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-16 09:48 |
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Publish the Manuscript Online |
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2026-03-30 08:58 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Review |
| Article Title |
Progress on the neurotrophic effects of antidepressant drugs
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pan Jing, Xi-Cheng Liu, Xiao-Peng Yin, Ye Fu, Qing Tian and Xiao-Bin Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ningbo Top Medical and Health Research Program |
2022030410 |
| Zhejiang Medical and Health Science and Technology Project |
2023KY1126 |
| Suzhou Clinical Medical Center for Mood Disorders |
Szlcyxzx202109 |
| Suzhou Key Laboratory |
SZS2024016 |
| Multicenter Clinical Research on Major Diseases in Suzhou |
DZXYJ202413 |
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| Corresponding Author |
Xiao-Bin Zhang, Department of Psychiatry, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, No. 11 Guangqian Road, Xiangcheng District, Suzhou 215137, Jiangsu Province, China. zhangxiaobim@163.com |
| Key Words |
Major depressive disorder; Neurotrophic factors; Synaptic plasticity; Neurogenesis; Antidepressant drugs |
| Core Tip |
Major depressive disorder (MDD) is a complex disorder involving multiple neurotransmitters and brain regions. In patients with MDD, alterations may occur in the stability and functionality of these neural networks, extending beyond mere chemical imbalances. Antidepressants have neurotrophic effects that can enhance synaptic connections and stimulate the growth of new neurons, thus helping restore the function of neural networks. Synaptic and neurogenic enhancements induced by antidepressants require time to manifest and develop. These advances may yield more effective and safer antidepressants and improve the use of existing medications for patients with MDD. |
| Publish Date |
2026-03-30 08:58 |
| Citation |
Jing P, Liu XC, Yin XP, Fu Y, Tian Q, Zhang XB. Progress on the neurotrophic effects of antidepressant drugs. World J Psychiatry 2026; 16(4): 115300 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i4/115300.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i4.115300 |
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