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Articles Published Processes
1/12/2026 10:07:43 AM | Browse: 0 | Download: 0
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Received |
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2025-10-15 09:08 |
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Peer-Review Started |
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2025-10-15 09:09 |
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First Decision by Editorial Office Director |
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2025-10-28 09:43 |
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Return for Revision |
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2025-10-28 09:43 |
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Revised |
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2025-11-05 14:04 |
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Publication Fee Transferred |
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2025-11-12 01:24 |
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Second Decision by Editor |
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2025-12-03 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-03 08:37 |
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Articles in Press |
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2025-12-03 08:37 |
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Edit the Manuscript by Language Editor |
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2025-12-17 10:44 |
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Typeset the Manuscript |
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2026-01-04 02:08 |
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Publish the Manuscript Online |
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2026-01-12 10:07 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Gut microbiota and the colorectal cancer tumor microenvironment: From carcinogenic mechanisms to therapeutic opportunities
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Ke Chen, Jia-Wei Zhao, Yu-Gang Wang, Chen Wang and Min Shi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82170638 |
| Natural Science Foundation of the Science and Technology Commission of Shanghai Municipality |
23ZR1458300 |
| Key Discipline Project of Shanghai Municipal Health System |
2024ZDXK0004 |
| Pujiang Project of Shanghai Magnolia Talent Plan |
24PJD098 |
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| Corresponding Author |
Min Shi, Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Changning District, Shanghai 200336, China. sm1790@shtrhospital.com |
| Key Words |
Gut microbiota; Tumor immune microenvironment; Colorectal cancer; Tumor stromal cells; Immune cells |
| Core Tip |
This minireview synthesizes current insights into how gut microbiota and their metabolites bidirectionally shape the colorectal cancer tumor microenvironment, moving beyond epithelial barrier disruption to delineate direct immunomodulatory effects on stromal and immune cells. We further highlight the translational potential of microbiota-targeting strategies, such as fecal microbiota transplantation and engineered microbes, in reprogramming the immunosuppressive niche to overcome therapy resistance. |
| Publish Date |
2026-01-12 10:07 |
| Citation |
Chen ZK, Zhao JW, Wang YG, Wang C, Shi M. Gut microbiota and the colorectal cancer tumor microenvironment: From carcinogenic mechanisms to therapeutic opportunities. World J Gastrointest Oncol 2026; 18(1): 115309 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i1/115309.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i1.115309 |
© 2004-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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