| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Si-Wei Xia, Huan Liu, Kai-Yao Yang, Yi-Jie Gao, Meng-Ru Zhang, Jing-Wen Zhou, De-Song Kong, Hong-Yan Wu, Feng Zhang and Li Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jiangsu Province Traditional Chinese Medicine Science and Technology Development Plan Project |
No. QN202304 |
| Jiangsu Province Traditional Chinese Medicine Science and Technology Development Plan Project |
No. ZD202402 |
| Jiangsu Province Traditional Chinese Medicine Science and Technology Development Plan Project |
No. QN202112 |
| National Natural Science Foundation of China |
No. 82173874 |
| National Natural Science Foundation of China |
No. 82274339 |
| Noncommunicable Chronic Diseases-National Science and Technology Major Project |
No. 2024ZD0530800 |
| Jiangsu Higher Education Institution Innovative Research Team for Science and Technology (2023) |
No. 56 |
| Jiangsu Province Engineering Research Center for Cardiovascular and Cerebrovascular Disease and Cancer Prevention and Control (2022) |
No. 85 |
| Postgraduate Research and Practice Innovation Program of Jiangsu Province |
No. KYCX242311 |
| Natural Science Foundation for Colleges and Universities in Jiangsu Province |
No. 23KJB360005 |
|
| Corresponding Author |
Li Chen, Lecturer, PhD, Jiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Nanjing 210023, Jiangsu Province, China. 300643@njucm.edu.cn |
| Key Words |
Hedyotis diffusa; Hepatic fibrosis; NR1D1; Hypoxia inducible factor-1; Urea cycle; Ammonia metabolism |
| Core Tip |
This study reveals a novel antifibrotic mechanism of Hedyotis diffusa, demonstrating that its bioactive components alleviate hepatic fibrosis by restoring expression of the circadian rhythm gene NR1D1 expression. NR1D1 acts as an upstream regulator, inhibiting hypoxia inducible factor-1 signaling and restoring urea cycle function, thereby reducing hepatic ammonia accumulation and interrupting the vicious cycle of ammonia-induced hepatic stellate cell activation. These findings position circadian rhythm-metabolism interplay as a promising therapeutic axis for liver fibrosis treatment. |
| Publish Date |
2026-03-02 08:37 |
| Citation |
Xia SW, Liu H, Yang KY, Gao YJ, Zhang MR, Zhou JW, Kong DS, Wu HY, Zhang F, Chen L. Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis. World J Gastroenterol 2026; 32(10): 115334 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i10/115334.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i10.115334 |
