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Articles Published Processes
5/20/2026 8:22:31 AM | Browse: 1 | Download: 0
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Received |
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2025-10-17 04:22 |
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Peer-Review Started |
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2025-10-17 04:22 |
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First Decision by Editorial Office Director |
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2025-11-30 01:50 |
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Return for Revision |
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2025-11-30 01:50 |
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Revised |
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2026-01-10 11:31 |
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Publication Fee Transferred |
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2026-01-12 10:59 |
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Second Decision by Editor |
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2026-03-12 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-12 09:05 |
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Articles in Press |
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2026-03-12 09:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-13 01:05 |
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Publish the Manuscript Online |
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2026-05-20 08:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
MFSD2A suppresses CD8+ T cell exhaustion in colorectal cancer by inhibiting ERK/p38 MAPK-PD-L1 signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shu-Jiong Feng, Yi-Feng Zhou, Jian-Feng Yang, Yi-Shen Mao, Wen-Li Ruan and Xiao-Feng Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical and Health Science and Technology Planning Project of Zhejiang Province |
2025KY1188 |
| The Key Research and Development Program of Zhejiang Province |
2023C03054 |
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| Corresponding Author |
Xiao-Feng Zhang, Department of Gastroenterology, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, No. 261 Huansha Road, Hangzhou 310000, Zhejiang Province, China. zhangxiaofengsy@sina.com |
| Key Words |
Colorectal cancer; Major facilitator superfamily domain containing 2A; Extracellular signal-regulated kinase; p38 mitogen-activated protein kinase; T cell exhaustion |
| Core Tip |
Major facilitator superfamily domain containing 2A, a known tumor suppressor and lipid transporter, is identified as a novel immune regulator in colorectal cancer. Major facilitator superfamily domain containing 2A exerts dual antitumor effects by suppressing the extracellular signal-regulated kinase/p38 mitogen-activated protein kinase-programmed death-ligand 1 signaling axis, thereby alleviating CD8+ T cell exhaustion and providing a potential strategy to overcome immunotherapy resistance in colorectal cancer. |
| Publish Date |
2026-05-20 08:22 |
| Citation |
Feng SJ, Zhou YF, Yang JF, Mao YS, Ruan WL, Zhang XF. MFSD2A suppresses CD8+ T cell exhaustion in colorectal cancer by inhibiting ERK/p38 MAPK-PD-L1 signaling. World J Gastroenterol 2026; 32(20): 115336 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i20/115336.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i20.115336 |
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