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5/21/2026 7:49:51 AM | Browse: 1 | Download: 0
Publication Name World Journal of Critical Care Medicine
Manuscript ID 115389
Country India
Received
2025-10-17 06:59
Peer-Review Started
2025-10-17 07:00
First Decision by Editorial Office Director
2025-11-30 01:33
Return for Revision
2025-11-30 01:33
Revised
2025-12-13 11:16
Publication Fee Transferred
Second Decision by Editor
2026-02-14 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-14 07:07
Articles in Press
2026-02-14 07:07
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-27 02:33
Publish the Manuscript Online
2026-05-21 07:49
ISSN 2220-3141(online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Critical Care Medicine
Manuscript Type Randomized Controlled Trial
Article Title Impact of magnesium on the clearance of lactate in critically sick patients with sepsis: Randomized clinical trial
Manuscript Source Invited Manuscript
All Author List Chakkaravarthe Anbarasan, Ankur Sharma, Nikhil Kothari, Tanvi M Meshram, Kamlesh Kumari, Shilpa Goyal and Pradeep K Bhatia
ORCID
Author(s) ORCID Number
Ankur Sharma http://orcid.org/0000-0001-9339-6988
Funding Agency and Grant Number
Corresponding Author Ankur Sharma, Additional Professor, Consultant, MD, Department of Trauma and Emergency (Anaesthesiology and Critical Care), All India Institute of Medical Sciences, Basni Industrial Area, Jodhpur 342008, Rājasthān, India. ankuranaesthesia@gmail.com
Key Words Lactate; Magnesium; Sepsis; Intensive care unit, Lactate clearance
Core Tip Early lactate clearance is a key therapeutic target and prognostic marker in sepsis. In this randomized clinical trial, magnesium supplementation significantly accelerated lactate clearance in critically ill patients with sepsis and was associated with reduced vasopressor requirements, shorter intensive care unit stay, and decreased overall hospital stay. Although the magnesium group demonstrated a numerically lower 28-day mortality, this difference did not reach statistical significance.
Publish Date 2026-05-21 07:49
Citation

Anbarasan C, Sharma A, Kothari N, Meshram TM, Kumari K, Goyal S, Bhatia PK. Impact of magnesium on the clearance of lactate in critically sick patients with sepsis: Randomized clinical trial. World J Crit Care Med 2026; 15(2): 115389

URL https://www.wjgnet.com/2220-3141/full/v15/i2/115389.htm
DOI https://dx.doi.org/10.5492/wjccm.v15.i2.115389
Full Article (PDF) WJCCM-15-115389-with-cover.pdf
CONSORT 2010 Statement 115389-CONSORT-2010-statement.pdf
Manuscript File 115389_Auto_Edited_072754.docx
Answering Reviewers 115389-answering-reviewers.pdf
Audio Core Tip 115389-audio.mp3
Biostatistics Review Certificate 115389-biostatistics-statement.pdf
Clinical Trial Registration Statement 115389-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form 115389-conflict-of-interest-statement.pdf
Copyright License Agreement 115389-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 115389-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 115389-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 115389-non-native-speakers.pdf
Supplementary Material 115389-supplementary-material.pdf
Peer-review Report 115389-peer-reviews.pdf
Scientific Misconduct Check 115389-scientific-misconduct-check.png
Scientific Editor Work List 115389-scientific-editor-work-list.pdf
CrossCheck Report 115389-crosscheck-report.pdf