| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
LIM domain only protein 7 promotes metastasis in colorectal cancer by TGF-β/ZEB1 pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue Bai, Bo Zheng, Xue-Mei Li, Juan-Dan Wang, Xiao-Hua Huang, Shu-Mei Fu and Xia Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The First Affiliated Hospital of Chengdu Medical College |
No. CYFY-GQ47 |
| Health Commission of Chengdu |
No. 2024253 |
| Chengdu Medical College |
No. 24LHXHZW1-04 |
| Project of “CMC Talents” Peak Plan of Chengdu Medical College |
No. 2024kjTzn06 |
|
| Corresponding Author |
Xia Chen, Chief Physician, MD, Professor, Department of Gastroenterology, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, No. 312 Baoguang Avenue Middle Section, Xindu District, Chengdu 610500, Sichuan Province, China. 970217858@qq.com |
| Key Words |
LIM domain only protein 7; Colorectal cancer; Metastasis; Epithelial-mesenchymal transition; Transforming growth factor-β; Zinc finger E-box binding homeobox 1 |
| Core Tip |
LIM domain only protein 7 (LMO7) is upregulated in colorectal cancer (CRC), and is correlated with clinical stage and metastasis. It promotes CRC cell proliferation, migration, invasion, epithelial-mesenchymal transition and tumor metastasis. transforming growth factor-β induces LMO7 expression by upregulating zinc finger E-box binding homeobox 1, which binds to the LMO7 promoter, forming a transforming growth factor-β/zinc finger E-box binding homeobox 1/LMO7 axis that drives CRC progression, highlighting LMO7 as a potential therapeutic target for CRC. |
| Publish Date |
2026-03-16 08:22 |
| Citation |
Bai X, Zheng B, Li XM, Wang JD, Huang XH, Fu SM, Chen X. LIM domain only protein 7 promotes metastasis in colorectal cancer by TGF-β/ZEB1 pathway. World J Gastroenterol 2026; 32(11): 115393 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i11/115393.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i11.115393 |
