Publication Name	World Journal of Nephrology
Manuscript ID	11542
Country	Brazil

Received	2014-05-27 09:00
Peer-Review Started	2014-05-27 11:56
To Make the First Decision	2014-06-27 11:53
Return for Revision	2014-06-27 17:56
Revised	2014-07-07 22:47
Second Decision	2014-07-29 09:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-29 10:09
Articles in Press	2014-07-29 10:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-30 16:24
Publish the Manuscript Online	2014-10-19 20:47

ISSN	2220-6124 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Renin-angiotensin system in the kidney: What is new?
Manuscript Source	Invited Manuscript
All Author List	Fernanda M Ferrão, Lucienne S Lara and Jennifer Lowe
Funding Agency and Grant Number	Funding Agency Grant Number Carlos Chagas Filho Rio de Janeiro State Research Foundation (FAPERJ) National Institute of Science and Technology for Structural Biology and Bioimaging, Brazilian National Research Council (CNPq)
Corresponding Author	Jennifer Lowe, MSc, PhD, Laboratório de Físico-Química Biológica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, UFRJ-CCS-Bloco G-Sala G1-037, Rio de Janeiro 21941-902, Brazil. lowe@biof.ufrj.br
Key Words	Renin-angiotensin system; Angiotensin Ⅱ; Kidney; Hypertension treatment; Receptor
Core Tip	Activation of the angiotensin converting enzyme (ACE)/ Angiotensin Ⅱ (Ang Ⅱ)/AT1 axis leads to vasoconstriction, anti-diuresis, anti-natriuresis, release of aldosterone and anti-diuretic hormone, which can result in hypertension, renal and cardiovascular diseases. Inhibition of renin and ACE or blocking AT1 receptor is the most used therapies for heart failure and hypertension. Nevertheless, the discovery of local Ang Ⅱ synthesis, new Ang Ⅱ metabolites, receptors and axis of this system, makes possible the development of new drugs and strategies for renal and cardiovascular diseases treatment, such as activation of ACE2/Ang-(1-7)/Mas axis, which presents opposite effects of AT1 activation by Ang Ⅱ.
Publish Date	2014-10-19 20:47
Citation	Ferrão FM, Lara LS, Lowe J. Renin-angiotensin system in the kidney: What is new? World J Nephrol 2014; 3(3): 64-76
URL	http://www.wjgnet.com/2220-6124/full/v3/i3/64.htm
DOI	http://dx.doi.org/10.5527/wjn.v3.i3.64

Full Article (PDF)	WJN-3-64.pdf
Full Article (Word)	WJN-3-64.doc
Manuscript File	11542-Review.doc
Answering Reviewers	11542-Answering reviewers.pdf
Copyright License Agreement	11542-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11542-Language certificate.pdf
Peer-review Report	11542-Peer review(s).pdf
Scientific Misconduct Check	11542-CrossCheck.jpg
Scientific Editor Work List	11542-Scientific editor work list.pdf