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Articles Published Processes
3/12/2026 9:18:16 AM | Browse: 4 | Download: 15
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Received |
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2025-10-22 03:01 |
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Peer-Review Started |
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2025-10-27 00:36 |
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First Decision by Editorial Office Director |
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2025-12-17 08:56 |
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Return for Revision |
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2025-12-17 08:56 |
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Revised |
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2025-12-26 06:23 |
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Publication Fee Transferred |
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2026-01-01 15:03 |
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Second Decision by Editor |
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2026-01-15 03:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-22 07:20 |
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Articles in Press |
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2026-01-22 07:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-01 10:38 |
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Publish the Manuscript Online |
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2026-03-12 09:18 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
PRDX2 silencing alleviates reactive hyperplasia of Müller glial cells in diabetic retinopathy by inhibiting the RhoA/ROCK signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Lan Du, Shuai Ouyang, Yu-Song Wang, Yi-Shuang Mao, Bei-Cheng Ren and Wei-Hong Yu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wei-Hong Yu, MD, PhD, Professor, Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing,China 100730, Beijing 100730, Beijing, China. yuweihongpumch@163.com |
| Key Words |
PPDX2; Diabetic retinopathy; Müller glial cells; Reactive gliosis; RhoA/ROCK |
| Core Tip |
This study identifies PRDX2 as a potential biomarker and mechanistic contributor in diabetic retinopathy (DR). PRDX2 was upregulated in both patient plasma and ocular tissues, with plasma levels showing a positive correlation with disease severity and serving as a significant predictor of proliferative DR. In vitro, PRDX2 silencing mitigated high-glucose-induced reactive hyperplasia in rat Müller cells. This effect was mediated by upregulation of RhoGDI1 and suppression of the downstream RhoA/ROCK signaling pathway. Targeting the PRDX2-RhoGDI1-RhoA axis may offer a novel therapeutic approach for alleviating neuroglial dysfunction in DR pathogenesis. |
| Publish Date |
2026-03-12 09:18 |
| Citation |
Du XL, Ouyang S, Wang YS, Mao YS, Ren BC, Yu WH. PRDX2 silencing alleviates reactive hyperplasia of Müller glial cells in diabetic retinopathy by inhibiting the RhoA/ROCK signaling pathway. World J Diabetes 2026; 17(3): 115433 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i3/115433.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i3.115433 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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