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Articles Published Processes
4/14/2026 8:58:01 AM | Browse: 2 | Download: 19
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Received |
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2025-10-16 12:08 |
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Peer-Review Started |
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2025-10-17 05:39 |
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First Decision by Editorial Office Director |
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2025-11-26 08:21 |
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Return for Revision |
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2025-11-26 08:21 |
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Revised |
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2025-12-03 07:09 |
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Publication Fee Transferred |
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2025-12-04 12:25 |
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Second Decision by Editor |
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2026-01-14 02:50 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-21 08:18 |
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Articles in Press |
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2026-01-21 08:18 |
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Edit the Manuscript by Language Editor |
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2026-01-29 03:19 |
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Typeset the Manuscript |
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2026-04-02 00:27 |
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Publish the Manuscript Online |
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2026-04-14 08:58 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Basic Study |
| Article Title |
EP300 drives renal fibrosis in diabetic nephropathy via histone acetyltransferase-mediated nephrocystin-4 expression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Si, Yao Dai, Guo-Ping Hu, Qiang Zhang, Fang Lv and Qiu Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Anhui Province Traditional Chinese Medicine Inheritance and Innovation Research Project |
No. 2024CCCX142 |
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| Corresponding Author |
Qiu Zhang, MD, PhD, Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, No. 136 Jixi Road, Hefei 230022, Anhui Province, China. zhangqiu@ahmu.edu.cn |
| Key Words |
EP300/nephrocystin-4; Diabetic nephropathy; Fibrosis; 27th lysine position of histone H3 modification; Targeted intervention |
| Core Tip |
Renal fibrosis is a key pathological process driving diabetic nephropathy progression, yet its epigenetic regulation remains unclear. This study identifies EP300 as a histone acetyltransferase that activates nephrocystin-4 transcription through 27th lysine position of histone H3 modification, promoting renal fibrosis. Inhibition of the EP300-nephrocystin-4 axis alleviates fibrotic injury and improves renal function in diabetic mice, providing new mechanistic insight and a potential therapeutic target for diabetic nephropathy. |
| Publish Date |
2026-04-14 08:58 |
| Citation |
Si W, Dai Y, Hu GP, Zhang Q, Lv F, Zhang Q. EP300 drives renal fibrosis in diabetic nephropathy via histone acetyltransferase-mediated nephrocystin-4 expression. World J Diabetes 2026; 17(4): 115437 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i4/115437.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i4.115437 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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