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Articles Published Processes
1/28/2026 9:23:38 AM | Browse: 89 | Download: 169
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Received |
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2025-10-17 13:16 |
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Peer-Review Started |
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2025-10-17 13:17 |
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First Decision by Editorial Office Director |
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2025-11-05 09:23 |
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Return for Revision |
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2025-11-05 09:23 |
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Revised |
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2025-11-17 10:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-15 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-15 07:32 |
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Articles in Press |
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2025-12-15 07:32 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-19 16:36 |
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Publish the Manuscript Online |
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2026-01-28 09:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Growth differentiation factor 15 - a new molecular target in inflammatory bowel disease: Progress and challenges
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jia Yang, Ya-Ting Pan and Hong-Zhu Wen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82274285 |
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| Corresponding Author |
Hong-Zhu Wen, Department of Gastroenterology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725 Wanping South Road, Xuhui District, Shanghai 200032, China. ellawhz@sina.com |
| Key Words |
Growth differentiation factor 15; Double-edged mediator; Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease |
| Core Tip |
The study by Ruiz-Malagón et al represents an important step toward elucidating the pathogenesis of inflammatory bowel disease, suggesting that growth differentiation factor 15 (GDF15) may contribute to disease development. GDF15 functions as a context-dependent mediator with both protective and pathogenic effects, and clarifying this duality remains a key objective for translational research. Current findings, derived largely from small observational cohorts, should be interpreted with caution and require validation in larger, independent populations. Ultimately, well-designed randomized controlled trials will be essential to establish more definitive evidence. |
| Publish Date |
2026-01-28 09:23 |
| Citation |
Yang J, Pan YT, Wen HZ. Growth differentiation factor 15 - a new molecular target in inflammatory bowel disease: Progress and challenges. World J Gastroenterol 2026; 32(5): 115439 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i5/115439.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i5.115439 |
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