| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Rheumatology |
| Manuscript Type |
Basic Study |
| Article Title |
Mesenchymal stem cells alleviate renal injury of lupus nephritis mice by reconstructing the immune microenvironment of renal tissue
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Jia He, Ming-Yao Meng, Chun-Kai Huang, Shi-Yuan Liu, Pu Wang, Wei Long, Hui Gao, Liu-San Yang, Shan He, Yan He, Yang-Fan Guo, Yi-Yi Zhao, Yuan Liu, Li-Rong Hu, Lin Li, Zong-Liu Hou, Wen-Ju Wang and Xiao-Dan Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81960136 |
| Science and Technology Department of Yunnan Province |
202401AY070001-048, 202501AY070001-040 |
| Scientific Research Fund Project of Yunnan Education Department |
2024Y244, 2025Y0387 |
|
| Corresponding Author |
Xiao-Dan Wang, Associate Chief Physician, MD, Key Laboratory of Engineering and Translational Application of Cell Derivatives of Yunnan Province, Yan’an Hospital Affiliated to Kunming Medical University, No. 245 Renmin East Road, Kunming 650051, Yunnan Province, China. wxdky001@163.com |
| Key Words |
Lupus nephritis; Umbilical cord mesenchymal stem cells; Regulatory T; T helper 17; Macrophages |
| Core Tip |
In our study, multiple immunofluorescence staining in renal tissue of lupus nephritis mice showed that after treatment with umbilical cord mesenchymal stem cells (UCMSCs), the proportion of regulatory T (Treg) was upregulated, while T helper 17 (Th17) decreased. The proportion of M2 cells increases, while M1 cells decreases. We further found that the proportion of Treg cells in the spleen of mice increased after UCMSCs treatment. In vitro experiments, we co-cultured UCMSCs with peripheral blood mononuclear cells and found that UCMSCs have inhibitory effects on Th1 and Th17 differentiation, as well as promoting Treg differentiation. It is suggested that UCMSCs may improve lupus nephritis by reconstructing the local immune microenvironment of the kidneys. |
| Publish Date |
2026-04-20 08:05 |
| Citation |
He LJ, Meng MY, Huang CK, Liu SY, Wang P, Long W, Gao H, Yang LS, He S, He Y, Guo YF, Zhao YY, Liu Y, Hu LR, Li L, Hou ZL, Wang WJ, Wang XD. Mesenchymal stem cells alleviate renal injury of lupus nephritis mice by reconstructing the immune microenvironment of renal tissue. World J Stem Cells 2026; 18(4): 115446 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i4/115446.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i4.115446 |
