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Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 115467
Country China
Received
2025-10-20 01:15
Peer-Review Started
2025-10-20 01:15
First Decision by Editorial Office Director
2025-11-24 12:50
Return for Revision
2025-11-25 01:07
Revised
2025-11-25 05:09
Publication Fee Transferred
Second Decision by Editor
2026-01-04 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-04 03:23
Articles in Press
2026-01-04 03:23
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-13 01:26
Publish the Manuscript Online
2026-04-24 10:11
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Editorial
Article Title Microbiota-bile acid crosstalk and hepatic gluconeogenesis after intestinal resection: Revisiting the gut-liver axis for metabolic recovery
Manuscript Source Invited Manuscript
All Author List Gang Wang and Sheng-Jie Pan
ORCID
Author(s) ORCID Number
Gang Wang http://orcid.org/0009-0009-8864-7688
Sheng-Jie Pan http://orcid.org/0009-0006-1274-7613
Funding Agency and Grant Number
Corresponding Author Gang Wang, MD, PhD, Professor, Department of General Surgery, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. 286651551@qq.com
Key Words Gut-liver axis; Bile acid signaling; Farnesoid X receptor; Glucagon-like peptide-1; Intestinal resection; Microbiota metabolism; Hepatic gluconeogenesis; Metabolic recovery; Immunometabolic adaptation; Precision surgery
Core Tip Intestinal resection reshapes systemic metabolism through coordinated microbiota-bile acid-hepatic signaling. Xu et al identified a 7-ketolithocholic acid-mediated farnesoid X receptor pathway linking microbial metabolism to suppression of hepatic gluconeogenesis. This editorial integrates these findings with broader immunometabolic and circadian mechanisms, emphasizing the role of bile acid signaling in postoperative metabolic adaptation. These insights highlight potential strategies for microbiota-targeted and receptor-based interventions to enhance metabolic recovery after surgery.
Publish Date 2026-04-24 10:11
Citation

Wang G, Pan SJ. Microbiota-bile acid crosstalk and hepatic gluconeogenesis after intestinal resection: Revisiting the gut-liver axis for metabolic recovery. World J Gastrointest Surg 2026; 18(4): 115467

URL https://www.wjgnet.com/1948-9366/full/v18/i4/115467.htm
DOI https://dx.doi.org/10.4240/wjgs.v18.i4.115467
Full Article (PDF) WJGS-18-115467-with-cover.pdf
Manuscript File 115467_Auto_Edited-YJP.docx
Answering Reviewers 115467-answering-reviewers.pdf
Audio Core Tip 115467-audio.mp3
Conflict-of-Interest Disclosure Form 115467-conflict-of-interest-statement.pdf
Copyright License Agreement 115467-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 115467-non-native-speakers.pdf
Peer-review Report 115467-peer-reviews.pdf
Scientific Misconduct Check 115467-scientific-misconduct-check.png
Scientific Editor Work List 115467-scientific-editor-work-list.pdf
CrossCheck Report 115467-crosscheck-report.pdf