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Articles Published Processes
3/15/2026 6:15:27 AM | Browse: 7 | Download: 12
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Received |
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2025-10-20 00:40 |
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Peer-Review Started |
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2025-10-20 00:40 |
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First Decision by Editorial Office Director |
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2025-11-14 07:57 |
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Return for Revision |
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2025-11-14 07:57 |
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Revised |
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2025-11-25 09:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-22 02:32 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-22 08:17 |
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Articles in Press |
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2026-01-22 08:17 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-28 06:46 |
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Publish the Manuscript Online |
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2026-03-15 06:15 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Deciphering the interplay between hypoxia, angiogenesis, and endoplasmic reticulum stress in carcinogenesis: A narrative review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shikha Bhardwaj, Shweta Pandey, Debasish Kumar Ghosh, Tapan Sharma and Buddhi Prakash Jain |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Buddhi Prakash Jain, Assistant Professor, Department of Zoology, Gene Expression and Signaling Lab., Mahatma Gandhi Central University, MGCUB, Motihari 845401, Bihar, India. buddhiprakash@mgcub.ac.in |
| Key Words |
Angiogenesis; Hypoxia; Endoplasmic reticulum stress; Cancer; Vascular endothelial growth factor; Hypoxia-inducible factor |
| Core Tip |
This review explores the interplay between hypoxia, endoplasmic reticulum stress and angiogenesis, highlighting the central regulatory role of hypoxia-inducible factors (HIFs). It highlights how HIF signaling links oxygen deprivation with vascular adaptation and protein-folding stress responses. Understanding this integrated network provides valuable insight into how tumors exploit these pathways for survival and offers potential molecular targets for therapeutic intervention. In future, this will lead to a better understanding of their synergistic relationship and how modulation of either pathway can potentially result in restraining the aggravated vasculogenesis which promotes the aberrant cell proliferation in cancer and in some case, make them more resistant to chemo and radiotherapy. |
| Publish Date |
2026-03-15 06:15 |
| Citation |
Bhardwaj S, Pandey S, Ghosh DK, Sharma T, Jain BP. Deciphering the interplay between hypoxia, angiogenesis, and endoplasmic reticulum stress in carcinogenesis: A narrative review. World J Exp Med 2026; 16(1): 115478 |
| URL |
https://www.wjgnet.com/2220-315x/full/v16/i1/115478.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v16.i1.115478 |
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