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Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 115487
Country China
Received
2025-10-20 10:01
Peer-Review Started
2025-10-20 10:01
First Decision by Editorial Office Director
2025-10-28 10:31
Return for Revision
2025-10-29 01:13
Revised
2025-11-06 16:40
Publication Fee Transferred
2025-11-09 15:27
Second Decision by Editor
2026-02-05 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-05 04:50
Articles in Press
2026-02-05 04:50
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-13 01:07
Publish the Manuscript Online
2026-04-24 10:11
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Report
Article Title Diagnostic challenges and multidisciplinary management of primary adenosquamous carcinoma of the liver: A case report and review of literature
Manuscript Source Unsolicited Manuscript
All Author List Rui-Biao Fu and Xiao-Feng Dong
ORCID
Author(s) ORCID Number
Rui-Biao Fu http://orcid.org/0000-0003-1962-3315
Xiao-Feng Dong http://orcid.org/0000-0003-2099-2652
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 82160589
Guangxi Science and Technology Major Project GuikeAA23073013
Corresponding Author Xiao-Feng Dong, PhD, Department of Hepatobiliary, Pancreatic and Spleen Surgery, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous Region, No. 6 Taoyuan Road, Qingxiu District, Nanning 530012, Guangxi Zhuang Autonomous Region, China. xfdong@gxams.org.cn
Key Words Primary adenosquamous carcinoma; Liver; Diagnosis; Clinical outcome; Case report
Core Tip In this report, we present a case of primary hepatic adenosquamous carcinoma that was initially misdiagnosed as a liver abscess. We highlight how markedly elevated carcinoembryonic antigen and cancer antigen 19-9 prompted further investigation, leading to surgical resection and pathologic confirmation. Importantly, we demonstrate promising short-term outcomes using a multimodal approach combining radical surgery with adjuvant lenvatinib and envafolimab. Our experience underscores the necessity of histopathologic diagnosis for adenosquamous carcinoma and suggests that aggressive combined modality therapy may improve survival in this highly aggressive malignancy.
Publish Date 2026-04-24 10:11
Citation

Fu RB, Dong XF. Diagnostic challenges and multidisciplinary management of primary adenosquamous carcinoma of the liver: A case report and review of literature. World J Gastrointest Surg 2026; 18(4): 115487

URL https://www.wjgnet.com/1948-9366/full/v18/i4/115487.htm
DOI https://dx.doi.org/10.4240/wjgs.v18.i4.115487
Full Article (PDF) WJGS-18-115487-with-cover.pdf
CARE Checklist–2016 115487-CARE-Checklist-2016.pdf
Manuscript File 115487_Auto_Edited_081656.docx
Answering Reviewers 115487-answering-reviewers.pdf
Audio Core Tip 115487-audio.m4a
Conflict-of-Interest Disclosure Form 115487-conflict-of-interest-statement.pdf
Copyright License Agreement 115487-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s) 115487-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate 115487-non-native-speakers.pdf
Peer-review Report 115487-peer-reviews.pdf
Scientific Misconduct Check 115487-scientific-misconduct-check.png
Scientific Editor Work List 115487-scientific-editor-work-list.pdf
CrossCheck Report 115487-crosscheck-report.pdf