| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hye Yeon Chon, Hyungjin Rhee, Jeehoon Kim, Galam Leem, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Seung Up Kim and Hee Seung Lee |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea (NRF) and Funded by the Korean Government (MIST) |
No. RS-2024-00342475 |
| National Research Foundation of Korea (NRF) and Funded by the Korean Government (MIST) |
No. RS-2024-00335625 |
| Korea Health Technology RD Project Through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare, Republic of Korea |
No. RS-2025-25458830 |
| Korea Health Technology RD Project Through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare, Republic of Korea |
No. RS-2025-25459146 |
|
| Corresponding Author |
Hee Seung Lee, Professor, Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. lhs6865@yuhs.ac |
| Key Words |
Hepatic steatosis; Pancreatic cancer; Liver metastases; Hepatic steatosis index; Metabolic dysfunction-associated steatotic liver disease |
| Core Tip |
Pancreatic cancer frequently spreads to the liver, contributing to its high mortality. With the rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), its potential impact on cancer outcomes remains uncertain. In this large cohort study of 2123 patients with pancreatic cancer, MASLD-defined by a hepatic steatosis index, was not associated with liver metastasis at diagnosis, new liver metastasis during follow-up or overall survival after adjustment for other risk factors. These findings suggest that MASLD does not significantly influence the metastatic pattern or prognosis in patients with pancreatic cancer. |
| Publish Date |
2026-03-16 08:22 |
| Citation |
Chon HY, Rhee H, Kim J, Leem G, Jo JH, Chung MJ, Park JY, Bang S, Park SW, Kim SU, Lee HS. Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer. World J Gastroenterol 2026; 32(11): 115488 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i11/115488.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i11.115488 |
