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Articles Published Processes
2/3/2026 6:28:06 AM | Browse: 1 | Download: 1
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Received |
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2025-10-20 10:15 |
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Peer-Review Started |
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2025-10-20 10:15 |
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First Decision by Editorial Office Director |
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2025-11-04 07:50 |
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Return for Revision |
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2025-11-04 07:50 |
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Revised |
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2025-11-12 15:58 |
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Publication Fee Transferred |
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2025-11-13 12:54 |
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Second Decision by Editor |
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2025-12-01 03:10 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-01 05:11 |
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Articles in Press |
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2025-12-01 05:11 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-26 08:27 |
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Publish the Manuscript Online |
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2026-02-03 06:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Impact of liver metastasis on the efficacy of immune checkpoint inhibitors for advanced colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng-Yue Xiang, Ze-Min Tuo, Xing-Kang Sa, Peng Wang, Ji-Wen Bian and Xin-Ming Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xin-Ming Zhang, Director, Department of General Surgery, Qingdao Traditional Chinese Medicine Hospital (Qingdao Hiser Hospital Affiliated of Qingdao University), No. 4 Renmin Road, Shibei District, Qingdao 266000, Shandong Province, China. 13963910911@163.com |
| Key Words |
Advanced colorectal cancer; Liver metastasis; Progression; Survival; Immune checkpoint inhibitors |
| Core Tip |
This meta-analysis evaluated the impact of liver metastasis on the efficacy of immune checkpoint inhibitors (ICIs) in advanced colorectal cancer (CRC). By pooling data from 16 studies involving 1203 patients, we found that liver metastasis was significantly associated with poorer progression-free and overall survival among ICI-treated patients. The adverse effect persisted across microsatellite instability subtypes and study designs, highlighting liver metastasis as a robust negative prognostic factor. These findings suggest that liver metastasis may impair systemic antitumor immunity and should be considered when optimizing immunotherapy strategies for metastatic CRC. |
| Publish Date |
2026-02-03 06:28 |
| Citation |
Xiang MY, Tuo ZM, Sa XK, Wang P, Bian JW, Zhang XM. Impact of liver metastasis on the efficacy of immune checkpoint inhibitors for advanced colorectal cancer. World J Gastrointest Oncol 2026; 18(2): 115515 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i2/115515.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i2.115515 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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