| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Vitamin D, vitamin D receptor gene polymorphisms, and inflammatory bowel disease outcomes: From molecular mechanisms to clinical application
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Beatriz Gabriela Costa, Ryan Nunes Yoshio Yoshihara, Amanda Luísa Spiller, Natalia Salvador Castelhano, Andrey Santos, Júlio Pinheiro Baima, Marcello Imbrizi, Maiara Brusco De Freitas, Daniéla Oliveira Magro and Ligia Yukie Sassaki |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ligia Yukie Sassaki, Assistant Professor, MD, PhD, Researcher, Department of Internal Medicine, Medical School, São Paulo State University (UNESP), Avenida Professor Montenegro, Distrito de Rubiao Junior, Botucatu 18618-686, São Paulo, Brazil. ligia.sassaki@unesp.br |
| Key Words |
Vitamin D; Vitamin D receptor; Genetic polymorphisms; Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease |
| Core Tip |
Vitamin D is essential in the pathogenesis and managing inflammatory bowel diseases. In addition to its classical bone metabolism function, vitamin D modulates intestinal epithelial integrity and immune responses. Genetic polymorphisms in the vitamin D receptor may influence disease activity and treatment outcomes. This minireview emphasizes the need for routine assessment of vitamin D status and consideration of vitamin D receptor genetic variants in personalized therapeutic strategies for inflammatory bowel diseases, especially in patients receiving immunosuppressive or biologic therapies. |
| Publish Date |
2026-04-15 06:47 |
| Citation |
Costa BG, Yoshihara RNY, Spiller AL, Castelhano NS, Santos A, Baima JP, Imbrizi M, De Freitas MB, Magro DO, Sassaki LY. Vitamin D, vitamin D receptor gene polymorphisms, and inflammatory bowel disease outcomes: From molecular mechanisms to clinical application. World J Gastroenterol 2026; 32(15): 115533 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i15/115533.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i15.115533 |
