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Articles Published Processes
2/27/2026 8:35:12 AM | Browse: 36 | Download: 143
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Received |
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2025-10-20 02:05 |
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Peer-Review Started |
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2025-10-20 02:05 |
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First Decision by Editorial Office Director |
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2025-11-21 09:59 |
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2025-11-21 09:59 |
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Revised |
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2025-12-02 22:02 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-14 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-14 08:40 |
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Articles in Press |
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2026-01-14 08:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-10 08:13 |
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Publish the Manuscript Online |
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2026-02-27 08:35 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Diagnosis and management of metabolic dysfunction-associated steatohepatitis in patients with chronic hepatitis B infection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Talal K Bhatti and Joseph K Lim |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Joseph K Lim, MD, Professor, Section of Digestive Diseases and Yale Liver Center, Yale University School of Medicine, 333 Cedar Street, LMP 1080, New Haven, CT 06520, United States. joseph.lim@yale.edu |
| Key Words |
Hepatitis B virus; Hepatic steatosis; Metabolic syndrome; Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis; Liver fibrosis; Clinical outcomes |
| Core Tip |
In context of a growing global burden of obesity and diabetes mellitus, metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic syndrome are increasingly observed in patients with chronic hepatitis B (CHB) virus infection. The relationship between hepatic steatosis and/or metabolic syndrome with CHB is complex and remains incompletely defined, although multiple cohort studies reveal an association with liver inflammation, liver fibrosis, hepatitis B virus (HBV)-related liver events such as cirrhosis, liver failure, and liver cancer, as well as biochemical and virologic response to antiviral therapy. Therefore, a dual diagnosis of MASLD and CHB, also termed met-HBV, may have important implications for management. Probable met-HBV can initially be identified on the basis of liver imaging, but a confirmed diagnosis can be established on vibration-controlled transient elastography-based controlled attenuation parameter score or liver biopsy. Patients diagnosed with met-HBV should undergo active management of MASLD and other manifestations of the metabolic syndrome. Future cohort studies and controlled trials are needed to inform evidence-based approaches to management. |
| Publish Date |
2026-02-27 08:35 |
| Citation |
Bhatti TK, Lim JK. Diagnosis and management of metabolic dysfunction-associated steatohepatitis in patients with chronic hepatitis B infection. World J Gastroenterol 2026; 32(9): 115544 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i9/115544.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i9.115544 |
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