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Articles Published Processes
3/30/2026 8:58:27 AM | Browse: 0 | Download: 0
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Received |
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2025-10-20 01:56 |
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Peer-Review Started |
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2025-10-20 01:56 |
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First Decision by Editorial Office Director |
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2025-11-06 08:44 |
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Return for Revision |
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2025-11-06 08:44 |
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Revised |
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2025-11-13 13:31 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-25 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-25 03:15 |
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Articles in Press |
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2025-12-25 03:15 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-19 00:37 |
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Publish the Manuscript Online |
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2026-03-30 08:58 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Review |
| Article Title |
Neuroimmune synapse and modulation by anesthetics: Inflammatory mechanisms and therapeutic perspectives for postoperative neurocognitive disorders
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yao Jie, Zhi-Wei Lai, Wen Zhou, You-Chun Li, Bao-Lin Zhong, Xin-Xing Zeng and Qiong Jiang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Qiong Jiang, Chief Physician, Department of Anesthesiology, Ganzhou People’s Hospital, No. 16 Meiguan Avenue, Ganzhou 341000, Jiangxi Province, China. m15979732601@163.com |
| Key Words |
Postoperative neurocognitive disorders; Neuroimmune synapse; Microglia-neuron interactions; Neuroinflammation; Anesthetic modulation; Complement system; Synaptic pruning |
| Core Tip |
This review reinterprets postoperative neurocognitive disorders through the concept of the neuroimmune synapse (NIS), the microglia, astrocyte, and neuron interface coordinating immune and neuronal signaling. We synthesize evidence on NIS pathways (CX3C chemokine ligand 1/CX3CR1, CD200/CD200R, complement, triggering receptor expressed on myeloid cells 2/DNAX activation protein of 12 kDa), show how anesthesia combined with surgical stress perturbs NIS function, and link aberrant microglial activation, excessive synaptic pruning, and hippocampal and prefrontal dysfunction to postoperative neurocognitive disorders. We further outline how distinct anesthetic classes modulate NIS structure and signaling, and propose testable interventions: Agent selection, multimodal analgesia, and targeting CX3CR1, triggering receptor expressed on myeloid cells 2, and complement to restore synaptic homeostasis. |
| Publish Date |
2026-03-30 08:58 |
| Citation |
Jie Y, Lai ZW, Zhou W, Li YC, Zhong BL, Zeng XX, Jiang Q. Neuroimmune synapse and modulation by anesthetics: Inflammatory mechanisms and therapeutic perspectives for postoperative neurocognitive disorders. World J Psychiatry 2026; 16(4): 115567 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i4/115567.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i4.115567 |
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