| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Hepatocellular carcinoma in F0 livers: Clinical and prognostic insights
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mizuki Endo, Koichi Honda, Tomoko Tokumaru, Tomoko Saito, Takuro Uchida, Masao Iwao, Mie Arakawa, Masataka Seike, Masaaki Kodama, Takashi Masuda, Yuichi Endo, Masafumi Inomata, Kazunari Murakami and Kazuhiro Mizukami |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mizuki Endo, Assistant Professor, Department of Gastroenterology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-Machi, Yufu 879-5593, Oita, Japan. emizuki@oita-u.ac.jp |
| Key Words |
Hepatocellular carcinoma; Nonfibrotic liver; Prognosis; Recurrence; Collaboration |
| Core Tip |
Hepatocellular carcinoma (HCC) arising in nonfibrotic (F0) livers is uncommon and its clinical behavior remains unclear. This study directly compared F0 and cirrhotic (F4) HCC, revealing that F0 HCC typically occurs in older men with negative for both hepatitis B and C etiology and larger tumors. Despite preserved liver function, recurrence significantly worsened prognosis. Tumor number was the sole independent risk factor for recurrence in F0 HCC. These findings emphasize the need for early detection strategies, even in non-cirrhotic populations. |
| Publish Date |
2026-04-08 07:28 |
| Citation |
Endo M, Honda K, Tokumaru T, Saito T, Uchida T, Iwao M, Arakawa M, Seike M, Kodama M, Masuda T, Endo Y, Inomata M, Murakami K, Mizukami K. Hepatocellular carcinoma in F0 livers: Clinical and prognostic insights. World J Gastrointest Oncol 2026; 18(4): 115576 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i4/115576.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i4.115576 |
