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Articles Published Processes
4/21/2026 8:57:42 AM | Browse: 4 | Download: 15
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Received |
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2025-10-22 11:10 |
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Peer-Review Started |
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2025-10-22 11:10 |
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First Decision by Editorial Office Director |
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2025-10-29 08:34 |
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Return for Revision |
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2025-10-29 08:34 |
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Revised |
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2025-11-11 11:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-20 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-20 09:16 |
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Articles in Press |
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2026-01-20 09:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-07 03:47 |
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Publish the Manuscript Online |
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2026-04-21 08:57 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://crativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Cell-free DNA in hepatocellular carcinoma: Biology to treatment response
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rishabh Sharma, Satender Pal Singh, Garima Bhatia and Gayatri Ramakrishna |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Satender Pal Singh, Department of Hepatology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, Delhi 110070, India. ama.satender@gmail.com |
| Key Words |
Cell-free DNA; Circulating tumor DNA; Hepatocellular carcinoma; Liquid biopsy; Methylation; Fragmentomics; Copy number variation; Chromosomal instability; Minimal residual disease; Treatment response |
| Core Tip |
The study evaluated circulating tumor DNA as a potential indicator of treatment response in hepatocellular carcinoma. Quantitative aspects of cell-free DNA, such as concentration and variant allele frequency, were analyzed in conjunction with qualitative genomic and epigenetic features, including copy-number variation and methylation-associated changes, to assess tumor dynamics during therapy. The findings indicate that cell-free DNA profiling captures both quantitative changes and molecular alterations, including genomic and epigenetic variation, that may reflect treatment-related tumor dynamics in hepatocellular carcinoma. |
| Publish Date |
2026-04-21 08:57 |
| Citation |
Sharma R, Singh SP, Bhatia G, Ramakrishna G. Cell-free DNA in hepatocellular carcinoma: Biology to treatment response. World J Hepatol 2026; 18(4): 115582 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i4/115582.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i4.115582 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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