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Publication Name World Journal of Methodology
Manuscript ID 115598
Country India
Received
2025-10-21 05:39
Peer-Review Started
2025-10-21 05:39
First Decision by Editorial Office Director
2025-12-05 09:15
Return for Revision
2025-12-05 09:15
Revised
2025-12-11 23:25
Publication Fee Transferred
Second Decision by Editor
2026-03-03 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-04 05:25
Articles in Press
2026-03-04 05:25
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-09 05:30
Publish the Manuscript Online
2026-07-10 10:11
ISSN 2222-0682 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Infectious Diseases
Manuscript Type Prospective Study
Article Title Stepwise model to differentiate pathogenic from non-pathogenic organisms in lower-respiratory isolates: Effectiveness and feasibility prospective cohort study
Manuscript Source Invited Manuscript
All Author List Shivnarayan Sahu, Balram Ji Omar, Mukesh Bairwa, Prakhar Sharma, Partha Sahu and Prasan Kumar Panda
ORCID
Author(s) ORCID Number
Prakhar Sharma http://orcid.org/0000-0002-6710-3499
Prasan Kumar Panda http://orcid.org/0000-0002-3008-7245
Funding Agency and Grant Number
Corresponding Author Prasan Kumar Panda, Professor, Internal Medicine (ID Division), All India Institute of Medical Sciences, Room No. 409, College Block, Rishikesh 249203, India. motherprasanna@rediffmail.com
Key Words Aerobic respiratory culture; Biofire FilmArray; Pathogen classification; Lower respiratory tract infections; Antimicrobial stewardship; Sequential Organ Failure Assessment score
Core Tip This prospective cohort study developed a structured clinico-microbiological model to distinguish true pathogens from colonizers in lower respiratory tract infections. Among 145 cases, 90% were identified as pathogens, with treatment outcomes aligning closely with the model’s classifications. The findings highlight that microbiological detection alone is insufficient for diagnosing infection - integrating clinical context and outcome data is crucial for rational antibiotic use and effective antimicrobial stewardship.
Publish Date 2026-07-10 10:11
Citation

Sahu S, Omar BJ, Bairwa M, Sharma P, Sahu P, Panda PK. Stepwise model to differentiate pathogenic from non-pathogenic organisms in lower-respiratory isolates: Effectiveness and feasibility prospective cohort study. World J Methodol 2026; 16(3): 115598

URL https://www.wjgnet.com/2222-0682/full/v16/i3/115598.htm
DOI https://doi.org/10.5662/wjm.115598
Full Article (PDF) WJM-16-115598-with-cover.pdf
CONSORT 2010 Statement 115598-CONSORT-2010-statement.pdf
Manuscript File 115598_Auto_Edited_094836.docx
Answering Reviewers 115598-answering-reviewers.pdf
Audio Core Tip 115598-audio.mp3
Biostatistics Review Certificate 115598-biostatistics-statement.pdf
Clinical Trial Registration Statement 115598-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form 115598-conflict-of-interest-statement.pdf
Copyright License Agreement 115598-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 115598-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 115598-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 115598-non-native-speakers.pdf
Supplementary Material 115598-supplementary-material.pdf
Peer-review Report 115598-peer-reviews.pdf
Scientific Misconduct Check 115598-scientific-misconduct-check.png
Scientific Editor Work List 115598-scientific-editor-work-list.pdf
CrossCheck Report 115598-crosscheck-report.pdf