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Publication Name World Journal of Stem Cells
Manuscript ID 115628
Country China
Received
2025-10-21 05:01
Peer-Review Started
2025-10-21 05:01
First Decision by Editorial Office Director
2025-11-18 07:43
Return for Revision
2025-11-18 07:43
Revised
2025-11-25 02:27
Publication Fee Transferred
Second Decision by Editor
2026-01-26 02:55
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-26 11:18
Articles in Press
2026-01-26 11:18
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-11 04:31
Publish the Manuscript Online
2026-09-24 06:23
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biology
Manuscript Type Editorial
Article Title Induced pluripotent stem cell-derived mesenchymal stem cell exosomes emerge as potent inducers of cancer cell senescence
Manuscript Source Invited Manuscript
All Author List Si-Feng Wang, Hai-Chun Guo, Xiao-Qin Gong and Xiang-Wen Peng
ORCID
Author(s) ORCID Number
Xiang-Wen Peng http://orcid.org/0000-0001-9110-5163
Funding Agency and Grant Number
Corresponding Author Xiang-Wen Peng, Associate Professor, Central Laboratory, Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, No. 416 Chengnan East Road, Yuhua District, Changsha 410001, Hunan Province, China. pxw1237@163.com
Key Words Induced pluripotent stem cell-derived mesenchymal stem cells; Bone marrow mesenchymal stem cells; Exosomes; Senescence-associated secretory phenotype; Cancer cell senescence
Core Tip This editorial emphasizes how exosomes from induced pluripotent stem cell-derived mesenchymal stem cells, not those from bone marrow, drive a potent, non-apoptotic antitumor response by inducing stable senescence in aggressive carcinomas, thereby redefining exosome source as a critical therapeutic variable and positioning senescence induction as a promising strategy for precision cancer therapy.
Publish Date 2026-09-24 06:23
Citation

Wang SF, Guo HC, Gong XQ, Peng XW. Induced pluripotent stem cell-derived mesenchymal stem cell exosomes emerge as potent inducers of cancer cell senescence. World J Stem Cells 2026; 18(9): 115628

URL https://www.wjgnet.com/1948-0210/full/v18/i9/115628.htm
DOI https://doi.org/10.4252/wjsc.115628
Full Article (PDF) WJSC-18-115628-with-cover.pdf
Manuscript File 115628_Auto_Edited_031500.docx
Answering Reviewers 115628-answering-reviewers.pdf
Audio Core Tip 115628-audio.m4a
Conflict-of-Interest Disclosure Form 115628-conflict-of-interest-statement.pdf
Copyright License Agreement 115628-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 115628-non-native-speakers.pdf
Peer-review Report 115628-peer-reviews.pdf
Scientific Misconduct Check 115628-scientific-misconduct-check.png
CrossCheck Report 115628-crosscheck-report.pdf