Publication Name	World Journal of Gastroenterology
Manuscript ID	11563
Country	China

Received	2014-05-28 11:30
Peer-Review Started
To Make the First Decision
Return for Revision
Revised	2014-06-17 20:31
Second Decision	2014-07-22 16:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-22 18:20
Articles in Press	2014-07-22 18:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-08-11 21:40
Typeset the Manuscript	2014-12-15 15:14
Publish the Manuscript Online	2015-01-06 09:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Bifidobacterium infantis attenuates colitis by regulating T cell subset responses
Manuscript Source	Unsolicited Manuscript
All Author List	Li Zuo, Kai-Tao Yuan, Li Yu, Qing-Hong Meng, Peter Chee-Keung Chung and Ding-Hua Yang
Funding Agency and Grant Number	Funding Agency Grant Number Guangzhou Baoxing Biotechnology Company
Corresponding Author	Ding-Hua Yang, MD, PhD, Professor, Department of Hepatobiliary Surgery, Nan Fang Hospital, Southern Medical University, 1838 North Guangzhou Dadao, Guangzhou 510515, Guangdong Province, China. dhyang5810@yahoo.com
Key Words	Bifidobacterium; Colitis; Cytokines; Th17; Regulatory T cells
Core Tip	Inflammatory bowel disease is a common autoimmune disorder characterized by chronic inflammation of the gastrointestinal tract. Abnormal immune cell responses contribute to the pathogenesis of the colitis. Probiotics are found to regulate the intestinal immune system and play a beneficial role in treating colitis. In our study, we showed that Bifidobacterium infantis (B. infantis) reduced the intestinal inflammation in TNBS-induced colitis mice though decreasing the Th1 and Th17 responses and promoting the Foxp3+ Treg response in mesenteric lymph nodes. This mechanism underlying the regulatory effect of B. infantis on the immune system may have significant clinical implications in treating inflammatory bowel disease and preventing colorectal cancer.
Publish Date	2015-01-06 09:08
Citation	Zuo L, Yuan KT, Yu L, Meng QH, Chung PCK, Yang DH. Bifidobacterium infantis attenuates colitis by regulating T cell subset responses. World J Gastroenterol 2014; 20(48): 18316-18329
URL	http://www.wjgnet.com/1007-9327/full/v20/i48/18316.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i48.18316

Full Article (PDF)	WJG-20-18316.pdf
Full Article (Word)	WJG-20-18316.doc
Manuscript File	11563-Review.docx
Answering Reviewers	11563-Answering reviewers.pdf
Copyright License Agreement	11563-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11563-Language certificate.pdf
Peer-review Report	11563-Peer review(s).pdf
Scientific Misconduct Check	11563-CrossCheck.jpg
Scientific Editor Work List	11563-Scientific editor work list.pdf