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1/6/2015 9:08:00 AM | Browse: 1159 | Download: 1258
Publication Name World Journal of Gastroenterology
Manuscript ID 11563
Country/Territory China
Received
2014-05-28 11:30
Peer-Review Started
To Make the First Decision
Return for Revision
Revised
2014-06-17 20:31
Second Decision
2014-07-22 16:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-22 18:20
Articles in Press
2014-07-22 18:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-08-11 21:40
Typeset the Manuscript
2014-12-15 15:14
Publish the Manuscript Online
2015-01-06 09:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Bifidobacterium infantis attenuates colitis by regulating T cell subset responses
Manuscript Source Unsolicited Manuscript
All Author List Li Zuo, Kai-Tao Yuan, Li Yu, Qing-Hong Meng, Peter Chee-Keung Chung and Ding-Hua Yang
Funding Agency and Grant Number
Funding Agency Grant Number
Guangzhou Baoxing Biotechnology Company
Corresponding Author Ding-Hua Yang, MD, PhD, Professor, Department of Hepatobiliary Surgery, Nan Fang Hospital, Southern Medical University, 1838 North Guangzhou Dadao, Guangzhou 510515, Guangdong Province, China. dhyang5810@yahoo.com
Key Words Bifidobacterium; Colitis; Cytokines; Th17; Regulatory T cells
Core Tip Inflammatory bowel disease is a common autoimmune disorder characterized by chronic inflammation of the gastrointestinal tract. Abnormal immune cell responses contribute to the pathogenesis of the colitis. Probiotics are found to regulate the intestinal immune system and play a beneficial role in treating colitis. In our study, we showed that Bifidobacterium infantis (B. infantis) reduced the intestinal inflammation in TNBS-induced colitis mice though decreasing the Th1 and Th17 responses and promoting the Foxp3+ Treg response in mesenteric lymph nodes. This mechanism underlying the regulatory effect of B. infantis on the immune system may have significant clinical implications in treating inflammatory bowel disease and preventing colorectal cancer.
Publish Date 2015-01-06 09:08
Citation Zuo L, Yuan KT, Yu L, Meng QH, Chung PCK, Yang DH. Bifidobacterium infantis attenuates colitis by regulating T cell subset responses. World J Gastroenterol 2014; 20(48): 18316-18329
URL http://www.wjgnet.com/1007-9327/full/v20/i48/18316.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i48.18316
Full Article (PDF) WJG-20-18316.pdf
Full Article (Word) WJG-20-18316.doc
Manuscript File 11563-Review.docx
Answering Reviewers 11563-Answering reviewers.pdf
Copyright License Agreement 11563-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 11563-Language certificate.pdf
Peer-review Report 11563-Peer review(s).pdf
Scientific Misconduct Check 11563-CrossCheck.jpg
Scientific Editor Work List 11563-Scientific editor work list.pdf