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Publication Name World Journal of Hepatology
Manuscript ID 115659
Country India
Received
2025-10-24 05:15
Peer-Review Started
2025-10-24 05:15
First Decision by Editorial Office Director
2025-11-18 10:59
Return for Revision
2025-11-18 11:08
Revised
2025-12-01 07:41
Publication Fee Transferred
Second Decision by Editor
2026-02-04 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-04 06:20
Articles in Press
2026-02-04 06:20
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-05-14 04:59
Publish the Manuscript Online
2026-05-26 03:52
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Kaempferol attenuates diet-induced obesity and hepatic steatosis in C57BL/6J mice fed an Indian diet-mimicking regimen
Manuscript Source Invited Manuscript
All Author List Bhagyalakshmi Nair, Rajesh Gopalakrishna and Lekshmi R Nath
ORCID
Author(s) ORCID Number
Bhagyalakshmi Nair http://orcid.org/0000-0002-0364-881X
Rajesh Gopalakrishna http://orcid.org/0000-0003-1101-5737
Lekshmi R Nath http://orcid.org/0000-0002-7726-7219
Funding Agency and Grant Number
Funding Agency Grant Number
the Amrita Vishwa Vidyapeetham Seed Grant K-PHAR-22-662
Corresponding Author Lekshmi R Nath, Associate Professor, PhD, Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Ponekkara PO, Kochi 682041, Kerala, India. lekshmirnath@aims.amrita.edu
Key Words Metabolic dysfunction-associated steatotic liver disease; Indian high fat diet; High calorie diet; Natural product; Kaempferol; Hepatic steatosis
Core Tip Metabolic dysfunction-associated steatotic liver disease spans from simple fat accumulation to cirrhosis and liver cancer, and its prevalence is steadily rising in India due to high fat, high sugar dietary habits. Kaempferol, a generally recognized as safe-approved flavonoid lipid-lowering effects, shows therapeutic potential but has not yet been evaluated in Indian diet-specific obesity driven liver disease models. This study demonstrates that kaempferol effectively attenuates diet-induced obesity and liver steatosis in C57BL/6J mice fed an Indian diet-mimicking regimen. The findings highlight kaempferol’s potential as a natural therapeutic agent for managing metabolic dysfunction and fatty liver disease associated with high calorie, region-specific dietary patterns.
Publish Date 2026-05-26 03:52
Citation

Nair B, Gopalakrishna R, Nath LR. Kaempferol attenuates diet-induced obesity and hepatic steatosis in C57BL/6J mice fed an Indian diet-mimicking regimen. World J Hepatol 2026; 18(5): 115659

URL https://www.wjgnet.com/1948-5182/full/v18/i5/115659.htm
DOI https://dx.doi.org/10.4254/wjh.v18.i5.115659
Full Article (PDF) WJH-18-115659-with-cover.pdf
The ARRIVE Guidelines 115659-The-ARRIVE-Guidelines.pdf
Manuscript File 115659_Auto_Edited_065607.docx
Answering Reviewers 115659-answering-reviewers.pdf
Audio Core Tip 115659-audio.mp3
Biostatistics Review Certificate 115659-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 115659-conflict-of-interest-statement.pdf
Copyright License Agreement 115659-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 115659-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document 115659-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 115659-non-native-speakers.pdf
Supplementary Material 115659-supplementary-material.pdf
Peer-review Report 115659-peer-reviews.pdf
Scientific Misconduct Check 115659-scientific-misconduct-check.png
Scientific Editor Work List 115659-scientific-editor-work-list.pdf
CrossCheck Report 115659-crosscheck-report.pdf