| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Kidney-bone axis: Emerging paradigms in cross-talk between renal function and skeletal health
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Guido Gembillo, Concetto Sessa, Luca Visconti, Andrea Corsonello, Antonino Catalano, Chiara Chinigò, Salvatore Silipigni, Maria Princiotto, Maria Elsa Gambuzza, Giuseppe Spadaro, Walter Morale, Luca Soraci and Domenico Santoro |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Guido Gembillo, Department of Clinical and Experimental Medicine, Department of Nephrology and Dialysis, AOU “G. Martino”, University of Messina, Via Consolare Valeria n 1, Messina 98100, Sicilia, Italy. gembillog@unime.it |
| Key Words |
Chronic kidney disease; Vitamin D; Renal failure; Osteoporosis; Cardiovascular disease |
| Core Tip |
The kidney-bone axis represents a bidirectional endocrine network extending beyond mineral metabolism. Chronic kidney disease affects hundreds of millions worldwide, causing substantially elevated fracture risk and mortality. Traditional biomarkers provide incomplete prognostic value, necessitating novel approaches. The fibroblast growth factor-Klotho pathway emerges as a critical mechanism regulating phosphate homeostasis, bone turnover, and cardiovascular complications, with alterations appearing early in disease progression. Understanding these integrated molecular pathways enables a paradigm shift from symptomatic management toward mechanism-based interventions, offering transformative potential for targeted therapies that simultaneously address skeletal fragility and systemic complications in chronic kidney disease-mineral and bone disorder. |
| Publish Date |
2026-04-10 07:08 |
| Citation |
Gembillo G, Sessa C, Visconti L, Corsonello A, Catalano A, Chinigò C, Silipigni S, Princiotto M, Gambuzza ME, Spadaro G, Morale W, Soraci L, Santoro D. Kidney-bone axis: Emerging paradigms in cross-talk between renal function and skeletal health. World J Orthop 2026; 17(4): 115663 |
| URL |
https://www.wjgnet.com/2218-5836/full/v17/i4/115663.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v17.i4.115663 |
