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Articles Published Processes
2/11/2026 7:19:22 AM | Browse: 0 | Download: 0
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Received |
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2025-10-22 11:16 |
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Peer-Review Started |
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2025-10-22 11:16 |
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First Decision by Editorial Office Director |
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2025-11-30 01:52 |
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Return for Revision |
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2025-11-30 01:52 |
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Revised |
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2025-12-13 16:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-04 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-04 07:43 |
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Articles in Press |
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2026-01-04 07:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-04 18:37 |
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Publish the Manuscript Online |
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2026-02-11 07:19 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Molecular mechanisms of tumor-associated macrophages in hepatocellular carcinoma development and therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ming Yang and Chun-Ye Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ming Yang, Department of Surgery, University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, United States. minyang@uchc.edu |
| Key Words |
Hepatocellular carcinoma; Macrophages; Immune checkpoint inhibitors; Immunotherapy; Signaling pathways |
| Core Tip |
As a predominant population of immune cells in the tumor microenvironment, tumor-associated macrophages (TAMs) play an important role in the initiation and progression of hepatocellular carcinoma (HCC). TAM-derived factors, including but not limited to cytokines, chemokines, and exosomes, regulate angiogenesis, immunosuppression, and therapeutic resistance in HCC. Strategies such as reprogramming TAM polarization, suppressing immunosuppressive cell recruitment, and inhibiting immunosuppressive signaling pathways can decrease tumor-promoting immune cell recruitment, reinforce the cytotoxicity of T cells, and retard tumor cell proliferation, ultimately slowing or delaying tumor growth. |
| Publish Date |
2026-02-11 07:19 |
| Citation |
Yang M, Zhang CY. Molecular mechanisms of tumor-associated macrophages in hepatocellular carcinoma development and therapy. World J Gastroenterol 2026; 32(8): 115675 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i8/115675.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i8.115675 |
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