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Articles Published Processes
5/14/2026 9:17:10 AM | Browse: 7 | Download: 51
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Received |
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2025-10-24 09:51 |
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Peer-Review Started |
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2025-10-24 09:51 |
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First Decision by Editorial Office Director |
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2025-11-04 10:09 |
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Return for Revision |
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2025-11-06 10:19 |
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Revised |
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2025-11-18 11:37 |
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Publication Fee Transferred |
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2025-11-25 07:41 |
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Second Decision by Editor |
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2026-01-26 02:58 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-26 07:44 |
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Articles in Press |
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2026-01-26 07:44 |
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Edit the Manuscript by Language Editor |
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2026-02-02 00:27 |
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Typeset the Manuscript |
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2026-04-28 00:15 |
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Publish the Manuscript Online |
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2026-05-14 09:17 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Icaritin suppresses colorectal cancer invasion and metastasis through regulation of epithelial-mesenchymal transition and the Wnt/β-catenin signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiang Li, Yan-Jiao Li, Dan-Dan Ren, Mei Yuan, Ya-Ru Qi, Hui-Wen Li, Yi Zhang and Ruo-Yu Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ruo-Yu Wang, Professor, Department of Oncology, Dalian Medical University, No. 9 West Section of Lushun South Road, Dalian 116044, Liaoning Province, China. wangruoyu@dlu.edu.cn |
| Key Words |
Colorectal cancer; Icaritin; Epithelial-mesenchymal transition; Wnt/β-catenin signaling pathway; Metastasis |
| Core Tip |
This study demonstrates that icaritin, a clinical anti-cancer agent, potently inhibits colorectal cancer metastasis by reversing the epithelial-mesenchymal transition and suppressing the Wnt/β-catenin signaling pathway. We provide novel mechanistic evidence that icaritin downregulates key metastatic drivers like N-cadherin, Snail, and matrix metalloproteinase 9 while restoring E-cadherin expression. These findings, validated in orthotopic mouse models, position icaritin as a promising therapeutic candidate for targeting advanced and metastatic colorectal cancer. |
| Publish Date |
2026-05-14 09:17 |
| Citation |
Li X, Li YJ, Ren DD, Yuan M, Qi YR, Li HW, Zhang Y, Wang RY. Icaritin suppresses colorectal cancer invasion and metastasis through regulation of epithelial-mesenchymal transition and the Wnt/β-catenin signaling pathway. World J Gastrointest Oncol 2026; 18(5): 115697 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i5/115697.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i5.115697 |
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