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2/2/2026 7:26:02 AM | Browse: 3 | Download: 8
Publication Name World Journal of Gastroenterology
Manuscript ID 115699
Country China
Received
2025-10-22 11:14
Peer-Review Started
2025-10-22 11:14
First Decision by Editorial Office Director
2025-12-02 08:35
Return for Revision
2025-12-02 08:35
Revised
2025-12-14 15:40
Publication Fee Transferred
Second Decision by Editor
2025-12-23 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-12-23 07:18
Articles in Press
2025-12-23 07:18
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-22 08:48
Publish the Manuscript Online
2026-02-02 07:26
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Editorial
Article Title Dyspepsia following Helicobacter pylori eradication: Shifts in etiology and clinical challenges
Manuscript Source Invited Manuscript
All Author List Jian-Guo Lu and Yi-Zhou Gao
ORCID
Author(s) ORCID Number
Yi-Zhou Gao http://orcid.org/0000-0003-3539-4647
Funding Agency and Grant Number
Corresponding Author Yi-Zhou Gao, Professor, Department of Environmental Hygiene, School of Public Health, Harbin Medical University, No. 157 Baojian Road, Nangang Distinct, Harbin 150081, Heilongjiang Province, China. gaoyizhou@yeah.net
Key Words Helicobacter pylori; Persistent dyspepsia; Therapeutic strategies; Etiology; Epidemiology
Core Tip Although Japan has made significant progress in Helicobacter pylori eradication and gastric cancer deaths have declined annually, many patients still suffer from dyspepsia. This challenges the traditional “test-and-eradicate” approach and places a heavy burden on patients. Suzuki et al’s large-scale study (n = 23250) revealed similar post-eradication dyspepsia prevalence (28.7%) to that in uninfected individuals, suggesting a shift from infection to functional factors, such as gastric acid secretion and visceral hypersensitivity. These findings call for individualized symptom-based management, rather than repeated eradication.
Publish Date 2026-02-02 07:26
Citation

Lu JG, Gao YZ. Dyspepsia following Helicobacter pylori eradication: Shifts in etiology and clinical challenges. World J Gastroenterol 2026; 32(6): 115699

URL https://www.wjgnet.com/1007-9327/full/v32/i6/115699.htm
DOI https://dx.doi.org/10.3748/wjg.v32.i6.115699
Full Article (PDF) WJG-32-115699-with-cover.pdf
Manuscript File 115699_Auto_Edited_111650.docx
Answering Reviewers 115699-answering-reviewers.pdf
Audio Core Tip 115699-audio.m4a
Conflict-of-Interest Disclosure Form 115699-conflict-of-interest-statement.pdf
Copyright License Agreement 115699-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 115699-non-native-speakers.pdf
Peer-review Report 115699-peer-reviews.pdf
Scientific Misconduct Check 115699-scientific-misconduct-check.png
Scientific Editor Work List 115699-scientific-editor-work-list.pdf
CrossCheck Report 115699-crosscheck-report.pdf