Publication Name	World Journal of Dermatology
Manuscript ID	11570
Country	France

Received	2014-05-28 10:52
Peer-Review Started	2014-05-28 17:38
To Make the First Decision	2014-07-29 12:02
Return for Revision	2014-07-30 09:52
Revised	2014-09-19 00:00
Second Decision	2014-12-31 12:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-31 13:28
Articles in Press	2014-12-31 13:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-16 13:49
Publish the Manuscript Online	2015-01-20 11:05

ISSN	2218-6190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Dermatology
Manuscript Type	Field of Vision
Article Title	Specificity in the alteration of lesional and non-lesional skin lipids in atopic dogs
Manuscript Source	Invited Manuscript
All Author List	Iuliana Popa, Jacques Portoukalian and Marek Haftek
Funding Agency and Grant Number
Corresponding Author	Iuliana Popa, Associate Professor, UMR 8612 CNRS, Faculty of Pharmacy, University Paris Sud XI, 5 rue J B Clement, 92290 Chatenay-Malabry, France. iuliana.popa@u-psud.fr
Key Words	Atopic dermatitis; Dogs; Glucosylceramide; Lipids; Ceramide; Stratum corneum
Core Tip	The review concerns the literature on modifi-cations of sphingolipids in the stratum corneum (SC) of atopic dogs. We gave for the first time a detailed biochemical analysis of dog lipids in the successive layers of the SC taken using tape stripping, and discussed their specificity by comparison to humans. We showed also the specific composition in protein-bound ceramides and the importance of CerOS in dog skin for barrier integrity. The lipid composition of involved and non-involved skin areas in atopic dogs was described and we showed how a topical or oral treatment can restore the lipid composition of SC and reconstruct the barrier integrity.
Publish Date	2015-01-20 11:05
Citation	Popa I, Portoukalian J, Haftek M. Specificity in the alteration of lesional and non-lesional skin lipids in atopic dogs. World J Dermatol 2015; 4(1): 1-7
URL	http://www.wjgnet.com/2218-6190/full/v4/i1/1.htm
DOI	http://dx.doi.org/10.5314/wjd.v4.i1.1

Manuscript File	11570-Review.docx
Answering Reviewers	11570-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	11570-Conflict-of-interest statement.pdf
Copyright License Agreement	11570-Copyright assignment.pdf
Peer-review Report	11570-Peer review(s).pdf
Scientific Misconduct Check	11570-CrossCheck.jpg
Scientific Editor Work List	11570-Scientific editor work list.pdf