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1/15/2026 3:16:57 AM | Browse: 1 | Download: 1
Publication Name World Journal of Obstetrics and Gynecology
Manuscript ID 115708
Country Kenya
Received
2025-10-24 06:28
Peer-Review Started
2025-10-24 06:28
First Decision by Editorial Office Director
2025-11-18 10:36
Return for Revision
2025-11-18 10:36
Revised
2025-11-19 13:53
Publication Fee Transferred
Second Decision by Editor
2025-12-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-12-25 06:22
Articles in Press
2025-12-25 06:22
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-12 10:57
Publish the Manuscript Online
2026-01-15 03:16
ISSN 2218-6220 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Obstetrics & Gynecology
Manuscript Type Case Report
Article Title Cryptococcal antigenemia during pregnancy: A case report
Manuscript Source Unsolicited Manuscript
All Author List Maureen Mueni Mark, Allan Kariuki Ng’ang’a, Felix Pius Omullo, Gudisa Bereda and Charles Tung’ani Muchiri
ORCID
Author(s) ORCID Number
Maureen Mueni Mark http://orcid.org/0009-7008-7431-5682
Allan Kariuki Ng’ang’a http://orcid.org/0009-0009-6664-0012
Felix Pius Omullo http://orcid.org/0009-0007-7431-1310
Gudisa Bereda http://orcid.org/0000-0002-5982-9601
Charles Tung’ani Muchiri http://orcid.org/0000-0001-9155-7709
Funding Agency and Grant Number
Corresponding Author Felix Pius Omullo, MD, Senior Researcher, Department of Medical Services, Equity Afya, Kanaamkemer, Lodwar 399-30500, Turkana, Kenya. piuskirasia@gmail.com
Key Words Cryptococcal antigenemia; Human immunodeficiency virus; Pregnancy; Fluconazole; Antiretroviral therapy; Immune reconstitution inflammatory syndrome; Perinatal transmission; Case report
Core Tip This case illustrates a high-stakes clinical dilemma in late pregnancy: Adhering to the standard 4-6 week antiretroviral therapy (ART) delay to prevent immune reconstitution inflammatory syndrome (IRIS) vs aggressively suppressing the human immunodeficiency virus viral load to prevent perinatal transmission. We demonstrate that for a woman presenting in the third trimester with isolated antigenemia, a truncated ART delay-supported by preemptive high-dose fluconazole and vigilant monitoring-was a calculated risk that achieved viral suppression for delivery without provoking IRIS. This case argues not for a new guideline, but for nuanced, individualized decision-making in complex scenarios, highlighting a critical evidence gap and the need to better define IRIS risk in pregnant women with antigenemia.
Publish Date 2026-01-15 03:16
Citation

Mark MM, Ng’ang’a AK, Omullo FP, Bereda G, Muchiri CT. Cryptococcal antigenemia during pregnancy: A case report. World J Obstet Gynecol 2026; 15(1): 115708

URL https://www.wjgnet.com/2218-6220/full/v15/i1/115708.htm
DOI https://dx.doi.org/10.5317/wjog.v15.i1.115708
Full Article (PDF) WJOG-15-115708-with-cover.pdf
CARE Checklist–2016 115708-CARE-Checklist-2016.pdf
Manuscript File 115708_Auto_Edited_093527.docx
Answering Reviewers 115708-answering-reviewers.pdf
Audio Core Tip 115708-audio.aac
Conflict-of-Interest Disclosure Form 115708-conflict-of-interest-statement.pdf
Copyright License Agreement 115708-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s) 115708-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate 115708-non-native-speakers.pdf
Peer-review Report 115708-peer-reviews.pdf
Scientific Misconduct Check 115708-scientific-misconduct-check.png
Scientific Editor Work List 115708-scientific-editor-work-list.pdf
CrossCheck Report 115708-crosscheck-report.pdf