| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Minireviews |
| Article Title |
What does the surgeon need to know about microsatellite instability in gastric cancers?
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Paulo Pimentel de Assumpção, Geraldo Ishak, Paula Baraúna de Assumpção, Samir Mansour Moraes Casseb, João Felipe Acioli, Sérgio Augusto Antunes Ramos, Jéssica Manoelli Costa Silva, Kauê Sant'Ana Pereira Guimarães, Carolina Baraúna de Assumpção, Paulo Kassab and Paul Mansfield |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Paulo Pimentel de Assumpção, Director, MD, PhD, Professor, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, R. dos Mundurucus, 4487 - Guamá, Belém - PA, 66073-000, Belém 66073-000, Pará, Brazil. assumpcaopp@gmail.com |
| Key Words |
Gastric cancer; Microsatellite instability; Mismatch repair; Immunotherapy; Surgical oncology |
| Core Tip |
This is an overview of the biological foundations, molecular mechanisms, diagnostic approaches, and clinical relevance of microsatellite instability in gastric cancer, emphasizing its role as a prognostic biomarker. The text also discusses therapeutic implications, including personalized surgical decision-making, treatment stratification, and the growing importance of integrating immunotherapy within multidisciplinary oncologic care. |
| Publish Date |
2026-04-08 07:28 |
| Citation |
de Assumpção PP, Ishak G, de Assumpção PB, Casseb SMM, Acioli JF, Ramos SAA, Silva JMC, Guimarães KSP, de Assumpção CB, Kassab P, Mansfield P. What does the surgeon need to know about microsatellite instability in gastric cancers? World J Gastrointest Oncol 2026; 18(4): 115719 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i4/115719.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i4.115719 |
