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Articles Published Processes
3/30/2026 8:58:27 AM | Browse: 0 | Download: 0
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Received |
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2025-10-24 02:55 |
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Peer-Review Started |
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2025-10-24 02:55 |
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First Decision by Editorial Office Director |
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2025-11-11 06:40 |
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Return for Revision |
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2025-11-11 06:40 |
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Revised |
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2025-11-19 22:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-25 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-25 03:04 |
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Articles in Press |
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2025-12-25 03:04 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-19 00:38 |
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Publish the Manuscript Online |
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2026-03-30 08:58 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Review |
| Article Title |
Depression and antidepressant drugs: Beyond a purely neurotransmitter approach
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Carlos M Contreras and Ana G Gutiérrez-García |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Carlos M Contreras, Emeritus Professor, MD, PhD, Senior Researcher, Unidad Periférica Xalapa, Instituto de Investigaciones Biomédicas, UNAM, Universidad Nacional Autónoma de México, Xalapa 91193, Veracruz, Mexico. ccontreras@uv.mx |
| Key Words |
Stress; Anxiety; Depression; Neuroinflammation; Cerebral plasticity; Antidepressants |
| Core Tip |
Antidepressant drug treatments have been classified based on their actions on neurotransmitters. However, these approaches have not reached solid conclusions about their mechanisms of action, their long latency to achieve clinical efficacy, or the pathophysiological processes that are involved in depression. Recent research suggests a continuum among stress, anxiety, and depression, in which the common denominator is neuroinflammation. Notably, NMDA receptor antagonists and classic antidepressants share actions on neurotrophic factors and glia-neuronal interactions. Therefore, one promising approach for the treatment of pathological anxiety and depression may lie in the search for antiinflammatory drugs with specific actions on neural tissue. |
| Publish Date |
2026-03-30 08:58 |
| Citation |
Contreras CM, Gutiérrez-García AG. Depression and antidepressant drugs: Beyond a purely neurotransmitter approach. World J Psychiatry 2026; 16(4): 115720 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i4/115720.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i4.115720 |
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