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Articles Published Processes
3/12/2026 12:25:35 PM | Browse: 1 | Download: 0
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Received |
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2025-10-24 02:49 |
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Peer-Review Started |
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2025-10-24 02:50 |
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First Decision by Editorial Office Director |
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2025-11-18 10:59 |
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Return for Revision |
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2025-11-20 06:46 |
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Revised |
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2025-12-09 07:19 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-30 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-30 08:30 |
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Articles in Press |
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2025-12-30 08:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-24 00:53 |
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Publish the Manuscript Online |
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2026-03-12 12:25 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Microbiota-driven immunometabolic regulation in colorectal cancer: Mechanisms and therapeutic opportunities
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wen-Yu Luan, Shu-Ping Zhang, Kai-Zhen Xu, Yu-Hui Shang, Wen-Jian Hu, Hui Sun and Yan-Dong Miao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Province Medical and Health Science and Technology Development Plan Project |
202203030713 |
| Yantai Science and Technology Program |
2024YD005 |
| Yantai Science and Technology Program |
2024YD007 |
| Yantai Science and Technology Program |
2024YD010 |
| Science and Technology Program of Yantai Affiliated Hospital of Binzhou Medical University |
YTFY2022KYQD06 |
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| Corresponding Author |
Yan-Dong Miao, Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, No. 717 Jinbu Street, Muping District, Yantai 264100, Shandong Province, China. miaoyd_22@bzmc.edu.cn |
| Key Words |
Colorectal cancer; Gut microbiota; Immunometabolism; Tumor microenvironment; Metabolic reprogramming |
| Core Tip |
The treatment of colorectal cancer (CRC) faces challenges of drug resistance mediated by the tumor microenvironment (TME). This review proposes that the gut microbiota is a core regulator in reshaping CRC immune metabolism and TME. We have established an integrated framework of the “microbiota-immune metabolism-TME” axis, systematically elaborating on the mechanisms of CRC occurrence, development, and treatment resistance from the micro level to the macro level. This perspective provides new ideas for deconstructing complexities such as clinical drug resistance. Based on this, we further explore translational strategies targeting the microbiota to reverse immunosuppression, enhance the efficacy of radiotherapy, chemotherapy, and immunotherapy, offering innovative theoretical basis and intervention prospects for the precise treatment of CRC. |
| Publish Date |
2026-03-12 12:25 |
| Citation |
Luan WY, Zhang SP, Xu KZ, Shang YH, Hu WJ, Sun H, Miao YD. Microbiota-driven immunometabolic regulation in colorectal cancer: Mechanisms and therapeutic opportunities. World J Gastrointest Oncol 2026; 18(3): 115722 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i3/115722.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i3.115722 |
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