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Publication Name World Journal of Gastroenterology
Manuscript ID 115731
Country China
Received
2025-10-23 08:37
Peer-Review Started
2025-10-23 08:37
First Decision by Editorial Office Director
2025-11-05 09:13
Return for Revision
2025-11-05 09:13
Revised
2025-11-18 08:03
Publication Fee Transferred
2025-11-19 02:38
Second Decision by Editor
2026-01-12 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-12 08:37
Articles in Press
2026-01-12 08:37
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-02-13 02:29
Publish the Manuscript Online
2026-03-02 08:37
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Gastrointestinal dysfunction after brain injury: Mechanisms and the role of the brain-gut axis
Manuscript Source Unsolicited Manuscript
All Author List Xia Zhao, Wei Zhang, Ying Zhang and Xing-An Liu
ORCID
Author(s) ORCID Number
Xia Zhao http://orcid.org/0000-0003-0233-3848
Xing-An Liu http://orcid.org/0000-0002-1185-6205
Funding Agency and Grant Number
Corresponding Author Xing-An Liu, Department Three of Brain Disease Rehabilitation, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Huaigu District, Shenyang 110032, Liaoning Province, China. liuxing_an@126.com
Key Words Brain injury; Gastrointestinal dysfunction; Brain-gut axis; Neuroinflammation; Gut microbiota
Core Tip Brain injury, including traumatic injury and stroke, frequently leads to gastrointestinal dysfunction, manifesting as dysmotility, increased permeability, and dysbiosis. This dysfunction impairs nutrition, increases infection risk, and exacerbates secondary brain damage via systemic inflammation. The brain-gut axis is central to this bidirectional interaction. Investigating interventions like probiotics and vagus nerve stimulation, which modulate this axis, offers promising therapeutic strategies for improving brain injury patient outcomes.
Publish Date 2026-03-02 08:37
Citation

Zhao X, Zhang W, Zhang Y, Liu XA. Gastrointestinal dysfunction after brain injury: Mechanisms and the role of the brain-gut axis. World J Gastroenterol 2026; 32(10): 115731

URL https://www.wjgnet.com/1007-9327/full/v32/i10/115731.htm
DOI https://dx.doi.org/10.3748/wjg.v32.i10.115731
Full Article (PDF) WJG-32-115731-with-cover.pdf
Manuscript File 115731_Auto_Edited_073628.docx
Answering Reviewers 115731-answering-reviewers.pdf
Audio Core Tip 115731-audio.mp3
Conflict-of-Interest Disclosure Form 115731-conflict-of-interest-statement.pdf
Copyright License Agreement 115731-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 115731-non-native-speakers.pdf
Peer-review Report 115731-peer-reviews.pdf
Scientific Misconduct Check 115731-scientific-misconduct-check.png
Scientific Editor Work List 115731-scientific-editor-work-list.pdf
CrossCheck Report 115731-crosscheck-report.pdf