BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
3/16/2026 8:15:36 AM | Browse: 41 | Download: 108
 |
Received |
|
2025-10-27 08:06 |
|
Peer-Review Started |
|
2025-10-27 08:06 |
|
First Decision by Editorial Office Director |
|
2025-11-21 09:41 |
|
Return for Revision |
|
2025-11-21 09:41 |
|
Revised |
|
2025-11-29 19:02 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2025-12-25 02:38 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-12-25 06:08 |
|
Articles in Press |
|
2025-12-25 06:08 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-03-06 00:59 |
|
Publish the Manuscript Online |
|
2026-03-16 08:15 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Machine learning identifies complement factor I as a shared mediator of periodontitis and ossification of posterior longitudinal ligament
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Nan Man, Lu-Yang Zhong, Yue-Liang Wen and Mao-Lin He |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Mao-Lin He, PhD, Division of Spinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. hemaolin@stu.gxmu.edu.cn |
| Key Words |
Ossification of the posterior longitudinal ligament; Periodontitis; Complement factor I; Discriminatory biomarker; Machine learning; Transcriptome; Single-cell RNA sequencing |
| Core Tip |
By integrating transcriptomics with machine learning across two distinct conditions, we identified complement factor I (CFI) as a candidate molecular mediator linking periodontitis and ossification of the posterior longitudinal ligament. This study provides the first computational evidence implicating a potential immune-endothelial axis, mediated by CFI, in the shared pathophysiology of these conditions. |
| Publish Date |
2026-03-16 08:15 |
| Citation |
Man YN, Zhong LY, Wen YL, He ML. Machine learning identifies complement factor I as a shared mediator of periodontitis and ossification of posterior longitudinal ligament. World J Orthop 2026; 17(3): 115770 |
| URL |
https://www.wjgnet.com/2218-5836/full/v17/i3/115770.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v17.i3.115770 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
