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Articles Published Processes
3/16/2026 8:15:36 AM | Browse: 8 | Download: 14
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Received |
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2025-10-27 08:06 |
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Peer-Review Started |
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2025-10-27 08:06 |
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First Decision by Editorial Office Director |
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2025-11-21 09:41 |
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Return for Revision |
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2025-11-21 09:41 |
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Revised |
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2025-11-29 19:02 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-25 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-25 06:08 |
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Articles in Press |
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2025-12-25 06:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-06 00:59 |
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Publish the Manuscript Online |
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2026-03-16 08:15 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Machine learning identifies complement factor I as a shared mediator of periodontitis and ossification of posterior longitudinal ligament
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Nan Man, Lu-Yang Zhong, Yue-Liang Wen and Mao-Lin He |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mao-Lin He, PhD, Division of Spinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. hemaolin@stu.gxmu.edu.cn |
| Key Words |
Ossification of the posterior longitudinal ligament; Periodontitis; Complement factor I; Discriminatory biomarker; Machine learning; Transcriptome; Single-cell RNA sequencing |
| Core Tip |
By integrating transcriptomics with machine learning across two distinct conditions, we identified complement factor I (CFI) as a candidate molecular mediator linking periodontitis and ossification of the posterior longitudinal ligament. This study provides the first computational evidence implicating a potential immune-endothelial axis, mediated by CFI, in the shared pathophysiology of these conditions. |
| Publish Date |
2026-03-16 08:15 |
| Citation |
Man YN, Zhong LY, Wen YL, He ML. Machine learning identifies complement factor I as a shared mediator of periodontitis and ossification of posterior longitudinal ligament. World J Orthop 2026; 17(3): 115770 |
| URL |
https://www.wjgnet.com/2218-5836/full/v17/i3/115770.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v17.i3.115770 |
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