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5/25/2026 7:47:53 AM | Browse: 50 | Download: 229
Publication Name World Journal of Stem Cells
Manuscript ID 115788
Country United States
Received
2025-10-27 08:06
Peer-Review Started
2025-10-27 08:11
First Decision by Editorial Office Director
2025-11-19 10:08
Return for Revision
2025-11-19 10:08
Revised
2025-12-01 19:09
Publication Fee Transferred
Second Decision by Editor
2026-01-12 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-12 12:44
Articles in Press
2026-01-12 12:44
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-05-13 01:15
Publish the Manuscript Online
2026-05-25 07:47
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Correspondence
Article Title Letter to the Editor: Exercise and induced pluripotent stem cells for Parkinson’s disease
Manuscript Source Unsolicited Manuscript
All Author List Emma Hughes and Brandon Lucke-Wold
ORCID
Author(s) ORCID Number
Emma Hughes http://orcid.org/0009-0000-4882-850X
Brandon Lucke-Wold http://orcid.org/0000-0001-6577-4080
Funding Agency and Grant Number
Corresponding Author Brandon Lucke-Wold, Lillian S Wells Department of Neurosurgery, University of Florida, 1505 SW Archer Road, Gainesville, FL 32608, United States. brandon.lucke-wold@neurosurgery.ufl.edu
Key Words Parkinson’s disease; Pluripotent stem cells; Neurodegeneration; Dopaminergic neurons; Wnt1; Lmx1a; Exercise
Core Tip This letter to the editor discusses the recent study by Jiang et al on induced pluripotent stem cells and exercise for Parkinson’s disease. Treatment with induced pluripotent stem cells provides a promising option for Parkinson’s disease patients by replacing lost dopaminergic neurons, while exercise alone has been shown to improve outcomes in these patients. A combination of these therapies has shown a potentially synergistic effect by activating the Wnt1-Lmx1a loop in a mouse model.
Publish Date 2026-05-25 07:47
Citation

Hughes E, Lucke-Wold B. Letter to the Editor: Exercise and induced pluripotent stem cells for Parkinson’s disease. World J Stem Cells 2026; 18(5): 115788

URL https://www.wjgnet.com/1948-0210/full/v18/i5/115788.htm
DOI https://dx.doi.org/10.4252/wjsc.v18.i5.115788
Full Article (PDF) WJSC-18-115788-with-cover.pdf