BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
4/29/2026 8:51:28 AM | Browse: 1 | Download: 0
 |
Received |
|
2025-10-27 11:22 |
|
Peer-Review Started |
|
2025-10-27 11:22 |
|
First Decision by Editorial Office Director |
|
2025-11-28 06:33 |
|
Return for Revision |
|
2025-11-28 06:33 |
|
Revised |
|
2025-12-14 01:02 |
|
Publication Fee Transferred |
|
2025-12-17 06:30 |
|
Second Decision by Editor |
|
2026-01-15 02:33 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-01-15 05:42 |
|
Articles in Press |
|
2026-01-15 05:42 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-04-14 01:58 |
|
Publish the Manuscript Online |
|
2026-04-29 08:51 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Review |
| Article Title |
Role of astrocytes in the development and progression of major depressive disorder
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Pan Jing, Chao Sun, Xiao-Peng Yin, Xi-Cheng Liu, Qing Tian and Xiao-Bin Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ningbo Top Medical and Health Research Program |
2022030410 |
| Zhejiang Medical and Health Science and Technology Project |
2023KY1126 |
| Suzhou Clinical Medical Center for Mood Disorders |
Szlcyxzx202109 |
| Suzhou Key Laboratory |
SZS2024016 |
| Multicenter Clinical Research on Major Diseases in Suzhou |
DZXYJ202413 |
|
| Corresponding Author |
Xiao-Bin Zhang, Department of Psychiatry, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, No. 11 Guangqian Road, Xiangcheng District, Suzhou 215137, Jiangsu Province, China. zhangxiaobim@163.com |
| Key Words |
Astrocytes; Major depressive disorder; Glial fibrillary acidic protein; S100β protein; Glial cell line-derived neurotrophic factor; Physiological functions |
| Core Tip |
Major depressive disorder is one of the most prevalent psychiatric illnesses worldwide which impairs the social functioning of the afflicted patients. Astrocytes play a role in the maintenance of the function of the central nervous system, both physiologically and pathologically. Increasing evidence suggests that the number, volume and function of astrocytes are altered in the depressed brain. The glial fibrillary acidic protein and S100β protein, which are closely associated with astrocytes, also show significant alterations in patients with major depressive disorder. Astrocyte-derived glial cell line-derived neurotrophic factor not only exerts neuroprotective effects in the central and peripheral nervous systems but also plays a role in depressive symptomatology and the pharmacological action of antidepressant treatments. |
| Publish Date |
2026-04-29 08:51 |
| Citation |
Jing P, Sun C, Yin XP, Liu XC, Tian Q, Zhang XB. Role of astrocytes in the development and progression of major depressive disorder. World J Psychiatry 2026; 16(5): 115794 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i5/115794.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i5.115794 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
