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Articles Published Processes
4/24/2026 10:11:08 AM | Browse: 0 | Download: 0
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Received |
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2025-11-21 09:12 |
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Peer-Review Started |
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2025-11-21 09:12 |
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First Decision by Editorial Office Director |
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2025-12-16 07:07 |
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Return for Revision |
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2025-12-16 07:07 |
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Revised |
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2025-12-19 10:49 |
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Publication Fee Transferred |
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2025-12-23 09:42 |
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Second Decision by Editor |
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2026-02-09 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-09 03:40 |
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Articles in Press |
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2026-02-09 03:40 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-13 01:56 |
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Publish the Manuscript Online |
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2026-04-24 10:11 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
T-LAK cell-originated protein kinase promotes tumorigenesis and metastasis of pancreatic neuroendocrine neoplasms via mitogen-activated protein kinase axis activation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng Meng, Qing Chen, Meng Yuan, Xin Guo, Si-Qian Ren and Chun-Hui Yuan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81672862 |
| the National Science and Technology Major Project of China |
2025ZD0552411 |
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| Corresponding Author |
Chun-Hui Yuan, MD, Department of General Surgery, Peking University Third Hospital, No. 49 Huayuan North Road, Haiding District, Beijing 100191, China. ychdoctor@bjmu.edu.cn |
| Key Words |
T-LAK cell-originated protein kinase; Pancreatic neuroendocrine neoplasms; Mitogen-activated protein kinase axis; Invasiveness and metastasis; HI-TOPK-032 |
| Core Tip |
Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare and typically slow growing but may lead to serious health complications. T-LAK cell-derived protein kinase is a serine/threonine kinase originally identified from a cDNA library of lymphokine-activated killer T cells and is overexpressed in multiple malignancies. This study demonstrates that T-LAK cell-derived protein kinase is markedly overexpressed in pNENs tissues with liver metastasis and further clarifies its effects on downstream signaling and the malignant biological behavior of pNENs. |
| Publish Date |
2026-04-24 10:11 |
| Citation |
Meng M, Chen Q, Yuan M, Guo X, Ren SQ, Yuan CH. T-LAK cell-originated protein kinase promotes tumorigenesis and metastasis of pancreatic neuroendocrine neoplasms via mitogen-activated protein kinase axis activation. World J Gastrointest Surg 2026; 18(4): 115798 |
| URL |
https://www.wjgnet.com/1948-9366/full/v18/i4/115798.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v18.i4.115798 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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