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Articles Published Processes
3/27/2026 6:07:04 AM | Browse: 35 | Download: 79
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Received |
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2025-10-27 12:39 |
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Peer-Review Started |
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2025-10-27 12:39 |
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First Decision by Editorial Office Director |
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2025-11-18 11:09 |
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Return for Revision |
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2025-11-18 11:09 |
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Revised |
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2025-11-29 08:12 |
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Publication Fee Transferred |
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2026-01-22 07:10 |
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Second Decision by Editor |
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2026-02-04 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-04 07:56 |
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Articles in Press |
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2026-02-04 07:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-17 05:52 |
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Publish the Manuscript Online |
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2026-03-27 06:07 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinical utility of genomic investigations in a Middle Eastern pediatric gastroenterology disease cohort
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ali Alsarhan, Rasha Alloush, Ruchi Jain, Ahmad Abou Tayoun and Christos Tzivinikos |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ahmad Abou Tayoun, Genomic Medicine Center, Dubai Health, Al Jalila Children Hospital, al jaddaf street, Dubai 00000, United Arab Emirates. ahmadat@gmail.com |
| Key Words |
Genomics; Diagnostic yield; Clinical utility; Middle East; Asia; Pediatrics |
| Core Tip |
Here we characterize the diagnostic and clinical utility of genomic investigations for a wide range of pediatric gastrointestinal disorders in a pediatric cohort from the Middle East. We show that the cumulative diagnostic yield was 55%, including 6% having multiple molecular diagnoses, mostly attributed to autosomal recessive disorders (66%). Yield was highest for patients with congenital diarrhea (73.3%) and cholestasis (62.5%). Genomic findings guided management plans in 97% of diagnosed patients. We propose a novel gene-disease association most likely due to biallelic loss-of-function variants in the NR1I3 gene. |
| Publish Date |
2026-03-27 06:07 |
| Citation |
Alsarhan A, Alloush R, Jain R, Abou Tayoun A, Tzivinikos C. Clinical utility of genomic investigations in a Middle Eastern pediatric gastroenterology disease cohort. World J Gastroenterol 2026; 32(13): 115810
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i13/115810.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i13.115810 |
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