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Articles Published Processes
3/23/2026 8:21:09 AM | Browse: 1 | Download: 11
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Received |
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2025-10-29 13:57 |
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Peer-Review Started |
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2025-10-29 13:57 |
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First Decision by Editorial Office Director |
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2025-11-19 10:11 |
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Return for Revision |
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2025-11-19 10:11 |
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Revised |
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2025-11-23 19:52 |
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Publication Fee Transferred |
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2025-11-24 02:21 |
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Second Decision by Editor |
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2026-01-12 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-12 07:32 |
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Articles in Press |
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2026-01-12 07:32 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-16 03:13 |
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Publish the Manuscript Online |
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2026-03-23 08:21 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Lactylation in pancreatic cancer: From molecular mechanisms to therapeutic perspectives
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gabriel Dickson Hawanga, Zhao-Xing Li, Mao-Xin Li, Xiu-Lei Zhang and Dao-Hai Qian |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dao-Hai Qian, Associate Chief Physician, Associate Professor, MD, PhD, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu 241001, Anhui Province, China. 20161106@wnmc.edu.cn |
| Key Words |
Lactylation; Epigenetic; Metabolic reprogramming; Lactate; Pancreatic ductal adenocarcinoma; Tumor microenvironment |
| Core Tip |
This mini-review highlights lactylation, a lactate-derived epigenetic modification, as a pivotal mechanism linking the intense glycolytic metabolism of pancreatic ductal adenocarcinoma to its aggressive phenotype. We synthesize how lactylation of histones and non-histone proteins drives oncogenic transcription, chemoresistance, and immune suppression. The article critically evaluates the promise of targeting lactylation “writers” and “erasers”, lactate transporters, and metabolic enzymes for therapy, while also discussing the challenges of specificity, drug delivery, and biomarker validation that must be addressed to translate these strategies to the clinic. |
| Publish Date |
2026-03-23 08:21 |
| Citation |
Hawanga GD, Li ZX, Li MX, Zhang XL, Qian DH. Lactylation in pancreatic cancer: From molecular mechanisms to therapeutic perspectives. World J Clin Oncol 2026; 17(3): 115882 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i3/115882.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i3.115882 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
