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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 115920
Country Germany
Received
2025-10-29 05:07
Peer-Review Started
2025-10-29 05:07
First Decision by Editorial Office Director
2025-12-09 06:57
Return for Revision
2025-12-09 06:57
Revised
2025-12-23 02:56
Publication Fee Transferred
Second Decision by Editor
2026-02-03 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-03 10:58
Articles in Press
2026-02-03 10:58
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-08 07:21
Publish the Manuscript Online
2026-08-07 09:40
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Correspondence
Article Title Letter to the Editor: Explainable artificial intelligence helps early cancer diagnosis via extracellular vesicle long RNA
Manuscript Source Invited Manuscript
All Author List Luis Augusto Eijy Nagai and Hui-Heng Jeremy Lin
ORCID
Author(s) ORCID Number
Luis Augusto Eijy Nagai http://orcid.org/0000-0002-7672-8554
Hui-Heng Jeremy Lin http://orcid.org/0000-0003-4060-7336
Funding Agency and Grant Number
Corresponding Author Luis Augusto Eijy Nagai, Associate Research Scientist, PhD, Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, University of Rostock, Ernst-Heydemann-Strasse 8, Rostock 18057, Mecklenburg-Vorpommern, Germany. eijynagai@gmail.com
Key Words Pancreatic ductal adenocarcinoma; Liquid biopsy; Extracellular vesicles; Long RNA; Explainable artificial intelligence; Machine learning
Core Tip Interpretable machine learning applied to extracellular vesicle long ribonucleic acid profiles is a promising direction for earlier pancreatic cancer detection and for differentiating pancreatic ductal adenocarcinoma from chronic pancreatitis. To accelerate clinical readiness, reported discrimination should be benchmarked against standard diagnostic pathways, validated across multiple centers with standardized pre-analytical processing, and accompanied by robustness checks that confirm explanation stability under realistic perturbations.
Publish Date 2026-08-07 09:40
Citation

Nagai LAE, Lin HHJ. Letter to the Editor: Explainable artificial intelligence helps early cancer diagnosis via extracellular vesicle long RNA. World J Gastrointest Oncol 2026; 18(8): 115920

URL https://www.wjgnet.com/1948-5204/full/v18/i8/115920.htm
DOI https://doi.org/10.4251/wjgo.115920
Full Article (PDF) WJGO-18-115920-with-cover.pdf
Manuscript File 115920_Auto_Edited_032652.docx
Answering Reviewers 115920-answering-reviewers.pdf
Audio Core Tip 115920-audio.mp3
Conflict-of-Interest Disclosure Form 115920-conflict-of-interest-statement.pdf
Copyright License Agreement 115920-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 115920-non-native-speakers.pdf
Peer-review Report 115920-peer-reviews.pdf
Scientific Misconduct Check 115920-scientific-misconduct-check.png
Scientific Editor Work List 115920-scientific-editor-work-list.pdf
CrossCheck Report 115920-crosscheck-report.pdf