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Articles Published Processes
9/25/2014 12:31:00 PM | Browse: 679 | Download: 761
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Received |
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2014-05-28 08:31 |
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Peer-Review Started |
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2014-05-29 11:13 |
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To Make the First Decision |
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2014-07-10 17:23 |
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Return for Revision |
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2014-07-11 15:11 |
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Revised |
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2014-08-09 00:00 |
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Second Decision |
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2014-09-01 15:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-09-01 15:18 |
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Articles in Press |
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2014-09-01 15:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-09-15 12:57 |
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Publish the Manuscript Online |
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2014-09-25 12:31 |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Training stem cells for treatment of malignant brain tumors
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shengwen Calvin Li, Mustafa H Kabeer, Long T Vu, Vic Keschrumrus, Hong Zhen Yin, Brent A Dethlefs, Jiang F Zhong, John H Weiss and William G Loudon |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The CHOC Children’s Foundation, CHOC Neuroscience Institute, CHOC Research Institute, The Austin Ford Tribute and Keck Foundation |
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| United States National Institutes of Health |
1R01CA164509-01 |
| United States National Science Foundation |
CHE-1213161 |
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| Corresponding Author |
Shengwen Calvin Li, PhD, Principal Investigator/Head, Neuro-Oncology and Stem Cell Research Laboratory, Center for Neuroscience Research, Children’s Hospital of Orange County, University of California-Irvine, 1201-D W. La Veta Avenue, Orange, CA 92868, United States. shengwel@uci.edu |
| Key Words |
Stem cells; Malignant brain tumors; Engineered tissue graft |
| Core Tip |
Neural stem cells can target malignant brain tumors in preclinical models; however, clinical trials show dismal efficacy. We reviewed the literature and .found that only a small fraction of applied stem cells can move toward tumors while the majority of stem cells cannot reach the target tumor. To fill in the gap in stem cell technology, we propose a solution to train stem cells in a native tissue environment, allowing them to move through tissue barriers and arrive at the target tumor. |
| Publish Date |
2014-09-25 12:31 |
| Citation |
Li SC, Kabeer MH, Vu LT, Keschrumrus V, Yin HZ, Dethlefs BA, Zhong JF, Weiss JH, Loudon WG. Training stem cells for treatment of malignant brain tumors. World J Stem Cells 2014; 6(4): 432-440 |
| URL |
http://www.wjgnet.com/1948-0210/full/v6/i4/432.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v6.i4.432 |
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