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5/13/2026 8:18:28 AM | Browse: 5 | Download: 40
Publication Name World Journal of Clinical Pediatrics
Manuscript ID 115963
Country Egypt
Received
2025-10-30 05:35
Peer-Review Started
2025-10-30 05:35
First Decision by Editorial Office Director
2025-11-30 01:33
Return for Revision
2025-11-30 01:33
Revised
2025-12-03 10:30
Publication Fee Transferred
Second Decision by Editor
2026-02-05 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-05 08:01
Articles in Press
2026-02-05 08:01
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-16 09:35
Publish the Manuscript Online
2026-05-13 08:18
ISSN 2219-2808 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pediatrics
Manuscript Type Systematic Reviews
Article Title Ultrasound hepatic elastography: A non-invasive indicator of insulin resistance in the pediatric population: A systematic review
Manuscript Source Invited Manuscript
All Author List Reem M Elbeltagi, Nermin K Saeed, Adel S Bediwy and Mohammed Al-Beltagi
ORCID
Author(s) ORCID Number
Reem M Elbeltagi http://orcid.org/0009-0008-3881-0961
Nermin K Saeed http://orcid.org/0000-0001-7875-8207
Adel S Bediwy http://orcid.org/0000-0002-0281-0010
Mohammed Al-Beltagi http://orcid.org/0000-0002-7761-9536
Funding Agency and Grant Number
Corresponding Author Mohammed Al-Beltagi, Chairman, Consultant, Full Professor, Head, MD, PhD, Professor, Senior Researcher, Department of Pediatrics, Faculty of Medicine, Tanta University, 1 Hassan Radwan Street, Tanta 31511, Algharbia, Egypt. mohamed.elbeltagi@med.tanta.edu.eg
Key Words Pediatric metabolic dysfunction-associated steatotic liver disease; Insulin resistance; Liver stiffness measurement; Controlled attenuation parameter; Transient elastography; Metabolic syndrome; Non-invasive biomarkers
Core Tip This systematic review and meta-analysis highlight that ultrasound-based hepatic elastography, through liver stiffness measurement and controlled attenuation parameter, provides a reliable, non-invasive reflection of insulin resistance (IR) in children and adolescents with metabolic dysfunction-associated steatotic liver disease. Controlled attenuation parameter effectively identifies early hepatic fat accumulation, while liver stiffness measurement detects fibrotic progression linked to chronic IR. The strongest correlations with adipose tissue IR and metabolic score-IR emphasize that elastography captures systemic metabolic dysfunction beyond the liver. These findings support its integration into pediatric screening and monitoring to guide early intervention and prevention of IR and steatotic liver disease.
Publish Date 2026-05-13 08:18
Citation

Elbeltagi RM, Saeed NK, Bediwy AS, Al-Beltagi M. Ultrasound hepatic elastography: A non-invasive indicator of insulin resistance in the pediatric population: A systematic review. World J Clin Pediatr 2026; 15(2): 115963

URL https://www.wjgnet.com/2219-2808/full/v15/i2/115963.htm
DOI https://dx.doi.org/10.5409/wjcp.v15.i2.115963
Full Article (PDF) WJCP-15-115963-with-cover.pdf
PRISMA 2009 Checklist 115963-PRISMA-2009-Checklist.pdf
Manuscript File 115963_Auto_Edited_070754-YJP.docx
Answering Reviewers 115963-answering-reviewers.pdf
Audio Core Tip 115963-audio.mp3
Biostatistics Review Certificate 115963-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 115963-conflict-of-interest-statement.pdf
Copyright License Agreement 115963-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 115963-non-native-speakers.pdf
Supplementary Material 115963-supplementary-material.pdf
Peer-review Report 115963-peer-reviews.pdf
Scientific Misconduct Check 115963-scientific-misconduct-check.png
Scientific Editor Work List 115963-scientific-editor-work-list.pdf
CrossCheck Report 115963-crosscheck-report.pdf