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Articles Published Processes
4/17/2026 7:16:58 AM | Browse: 38 | Download: 262
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Received |
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2025-11-03 06:51 |
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Peer-Review Started |
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2025-11-03 06:51 |
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First Decision by Editorial Office Director |
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2025-12-03 10:26 |
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Return for Revision |
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2025-12-03 10:26 |
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Revised |
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2025-12-15 04:28 |
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Publication Fee Transferred |
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2025-12-19 10:40 |
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Second Decision by Editor |
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2026-01-26 02:58 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-26 06:58 |
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Articles in Press |
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2026-01-26 06:58 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-07 03:22 |
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Publish the Manuscript Online |
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2026-04-17 07:16 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Age-related gut microbiome profile and reversal of microbial imbalance by trimetazidine intervention
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue-Mei Wang, Ben-Chen Rao, Guan-Yue Su, Hai-Yu Wang, Gui-Zhen Zhang, Fei-Lin Ge, Zu-Jiang Yu, Zhi-Gang Ren and Hong-Xia Liang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82470654 |
| Natural Science Foundation Key Project of Henan Province |
No. 232300421124 |
| Henan Zhongyuan Medical Science and Technology Innovation and Development Foundation |
No. ZYYC202301ZD |
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| Corresponding Author |
Hong-Xia Liang, Department of Infectious Disease and Hepatology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, Henan Province, China. hxliang@zzu.edu.cn |
| Key Words |
Intestinal microbiota; Dysbiosis; Lipid metabolism; Trimetazidine; Senescence |
| Core Tip |
This study reveals that gut microbiota alterations during aging follow a nonlinear trajectory across human and rat cohorts. The key finding demonstrates increased fatty acid oxidation-related microbiota in aged individuals. Functional enrichment analysis revealed a possible association between the gut microbiota and lipid metabolism. Trimetazidine (TMZ), a fatty acid oxidation inhibitor, successfully modulated aging-associated gut microbiota and suppressed senescence markers P21 in rats. These findings establish fatty acid oxidation maybe as a crucial mechanistic link between gut microbiota and aging, positioning TMZ as a potential therapeutic intervention for healthy aging through microbiome regulation. |
| Publish Date |
2026-04-17 07:16 |
| Citation |
Wang XM, Rao BC, Su GY, Wang HY, Zhang GZ, Ge FL, Yu ZJ, Ren ZG, Liang HX. Age-related gut microbiome profile and reversal of microbial imbalance by trimetazidine intervention. World J Gastroenterol 2026; 32(16): 115969 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i16/115969.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i16.115969 |
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