| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Chinese herbal formulas alleviated depression in breast cancer patients: A meta-analysis, network pharmacology and experimental validation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Cui Hong, Yu-Yi Du, Gui-Bin Wang, Sheng-Qi Wang, Yi-Feng Zheng, Neng Wang, Hong-Lin Situ and Zhi-Yu Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82374446, 82174165, 82474512 |
| State Key Laboratory of Dampness Syndrome of Chinese Medicine |
SZ2021ZZ19 |
| Science and Technology Planning Project of Guangdong Province |
2022B1515230002, 2023B1212060063 |
| Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research |
2020B1212030006 |
| Guangzhou Science and Technology Project |
2025CX009, 2023A03J0236 |
| Guangdong Traditional Chinese Medicine Bureau Project |
20231143 |
| Specific Research Fund for CHF Science and Technology of Guangdong Provincial Hospital of Chinese Medicine |
YN2023MS31 |
|
| Corresponding Author |
Zhi-Yu Wang, Full Professor, Principal Investigator, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou 510000, Guangdong Province, China. wangzhiyu@gzucm.edu.cn |
| Key Words |
Meta-analysis; Traditional Chinese medicine; Breast cancer; Depression; Si-Ni-San |
| Core Tip |
In present study, we found that Chinese herbal formulas outperformed antidepressants in reducing depression and improving quality of life, significantly elevated monoamine neurotransmitter levels, and selectively increased CD4+ T-cell counts. Network pharmacology revealed that Si-Ni-San may modulate immune responses and serotonergic synapses, while experimental validation indicated involvement of CD4+ T cells and rebalancing of neurotransmitter, tryptophan metabolism. These results advocate for the integration of Chinese herbal formulas especially Si-Ni-San into integrative care protocols for breast cancer-related depression and underscore the need for further mechanistic and clinical investigation. |
| Publish Date |
2026-03-30 08:58 |
| Citation |
Hong SC, Du YY, Wang GB, Wang SQ, Zheng YF, Wang N, Situ HL, Wang ZY. Chinese herbal formulas alleviated depression in breast cancer patients: A meta-analysis, network pharmacology and experimental validation. World J Psychiatry 2026; 16(4): 115981 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i4/115981.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i4.115981 |
