BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
3/30/2026 8:58:29 AM | Browse: 49 | Download: 95
 |
Received |
|
2025-10-31 07:08 |
|
Peer-Review Started |
|
2025-10-31 07:08 |
|
First Decision by Editorial Office Director |
|
2025-12-11 07:44 |
|
Return for Revision |
|
2025-12-11 07:44 |
|
Revised |
|
2025-12-16 15:17 |
|
Publication Fee Transferred |
|
2025-12-20 10:38 |
|
Second Decision by Editor |
|
2026-01-15 02:37 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-01-15 08:28 |
|
Articles in Press |
|
2026-01-15 08:28 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-03-16 09:49 |
|
Publish the Manuscript Online |
|
2026-03-30 08:58 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Chinese herbal formulas alleviated depression in breast cancer patients: A meta-analysis, network pharmacology and experimental validation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Cui Hong, Yu-Yi Du, Gui-Bin Wang, Sheng-Qi Wang, Yi-Feng Zheng, Neng Wang, Hong-Lin Situ and Zhi-Yu Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82374446, 82174165, 82474512 |
| State Key Laboratory of Dampness Syndrome of Chinese Medicine |
SZ2021ZZ19 |
| Science and Technology Planning Project of Guangdong Province |
2022B1515230002, 2023B1212060063 |
| Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research |
2020B1212030006 |
| Guangzhou Science and Technology Project |
2025CX009, 2023A03J0236 |
| Guangdong Traditional Chinese Medicine Bureau Project |
20231143 |
| Specific Research Fund for CHF Science and Technology of Guangdong Provincial Hospital of Chinese Medicine |
YN2023MS31 |
|
| Corresponding Author |
Zhi-Yu Wang, Full Professor, Principal Investigator, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou 510000, Guangdong Province, China. wangzhiyu@gzucm.edu.cn |
| Key Words |
Meta-analysis; Traditional Chinese medicine; Breast cancer; Depression; Si-Ni-San |
| Core Tip |
In present study, we found that Chinese herbal formulas outperformed antidepressants in reducing depression and improving quality of life, significantly elevated monoamine neurotransmitter levels, and selectively increased CD4+ T-cell counts. Network pharmacology revealed that Si-Ni-San may modulate immune responses and serotonergic synapses, while experimental validation indicated involvement of CD4+ T cells and rebalancing of neurotransmitter, tryptophan metabolism. These results advocate for the integration of Chinese herbal formulas especially Si-Ni-San into integrative care protocols for breast cancer-related depression and underscore the need for further mechanistic and clinical investigation. |
| Publish Date |
2026-03-30 08:58 |
| Citation |
Hong SC, Du YY, Wang GB, Wang SQ, Zheng YF, Wang N, Situ HL, Wang ZY. Chinese herbal formulas alleviated depression in breast cancer patients: A meta-analysis, network pharmacology and experimental validation. World J Psychiatry 2026; 16(4): 115981 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i4/115981.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i4.115981 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
