Publication Name	World Journal of Gastroenterology
Manuscript ID	11599
Country	United States

Received	2014-05-28 12:07
Peer-Review Started	2014-05-28 21:09
First Decision by Editorial Office Director
Return for Revision	2014-07-17 15:03
Revised	2014-08-27 10:51
Publication Fee Transferred
Second Decision by Editor	2014-11-10 11:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-11-19 09:16
Articles in Press	2014-11-19 09:43
Edit the Manuscript by Language Editor	2014-11-20 18:16
Typeset the Manuscript	2014-12-11 15:32
Publish the Manuscript Online	2014-12-20 19:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy
Manuscript Source	Invited Manuscript
All Author List	Ting-Ting Li, Shuji Ogino and Zhi Rong Qian
Funding Agency and Grant Number	Funding Agency Grant Number United States National Institute of Health (NIH) P01 CA87969 (to SE Hankinson) United States National Institute of Health (NIH) UM1 CA167552 United States National Institute of Health (NIH) P01 CA55075 (to WC Willett) United States National Institute of Health (NIH) R01 CA137178 (to AT Chan) United States National Institute of Health (NIH) P50 CA127003 (to CS Fuchs) United States National Institute of Health (NIH) R01 CA151993 (to S Ogino) Bennett Family Fund for Targeted Therapies Research Entertainment Industry Foundation through National Colorectal Cancer Research Alliance
Corresponding Author	Zhi-Rong Qian, MD, PhD, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave., Room M420, Boston, MA 02215, United States. zhirong_qian@dfci.harvard.edu
Key Words	Toll-like receptor; Colorectal cancer; Carcinogenesis; Prognosis; Cancer therapy
Core Tip	Toll-like receptors (TLRs) are innate immune sensors which can recognize inflammatory mediators. TLRs have been shown to mediate inflammatory response and maintain epithelial barrier homeostasis. Inflammation is a risk factor for many cancers including colorectal cancer (CRC). The key molecules involved in inflammation-driven carcinogenesis include TLRs. In this paper, we reviewed TLR signaling in CRC from carcinogenesis to cancer therapy.
Publish Date	2014-12-20 19:42
Citation	Li TT, Ogino S, Qian ZR. Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy. World J Gastroenterol 2014; 20(47): 17699-17708
URL	http://www.wjgnet.com/1007-9327/full/v20/i47/17699.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i47.17699

Full Article (PDF)	WJG-20-17699.pdf
Full Article (Word)	WJG-20-17699.doc
Manuscript File	11599-Review.doc
Answering Reviewers	11599-Answering reviewers.pdf
Copyright License Agreement	11599-Copyright assignment.pdf
Peer-review Report	11599-Peer review(s).pdf
Scientific Misconduct Check	11599-CrossCheck.jpg
Scientific Editor Work List	11599-Scientific editor work list.pdf