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Articles Published Processes
5/28/2026 8:52:32 AM | Browse: 0 | Download: 0
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Received |
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2025-10-31 05:41 |
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Peer-Review Started |
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2025-10-31 05:41 |
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First Decision by Editorial Office Director |
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2025-11-14 02:02 |
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Return for Revision |
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2025-11-14 02:02 |
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Revised |
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2026-01-09 18:18 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-02 03:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-02 04:58 |
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Articles in Press |
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2026-02-02 04:58 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-15 10:28 |
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Publish the Manuscript Online |
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2026-05-28 08:52 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychology, Multidisciplinary |
| Manuscript Type |
Review |
| Article Title |
Post-stroke depression update 2025: Mechanisms, prediction, and management
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jia-Xi Gu, Chao-Qiang Liu, Guang-Xi Chen, Tao Yao, Zhao-Xia Sun and Yong Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yong Wang, Researcher, Department of Internal Medicine, Yanbian University Hospital, No. 1327 Juzi Road, Yanji 133000, Jilin Province, China. wangyong0327ybu@163.com |
| Key Words |
Post-stroke depression; Risk factors; Neuroinflammation; Gut-brain axis; Precision medicine |
| Core Tip |
Post-stroke depression risk is refined by emerging biomarkers like vitamin D deficiency, hyperhomocysteinemia, and insulin resistance, alongside traditional factors. Multi-omics and artificial intelligence-driven models integrating clinical, neuroimaging, and inflammatory data show high predictive potential for precision stratification. Mechanistically, microglial/astrocytic polarization-driven neuroinflammation and gut-brain axis dysregulation are key therapeutic targets. Beyond first-line selective serotonin reuptake inhibitors, agomelatine, vitamin D supplementation, anti-inflammatory strategies, and evidence-based traditional Chinese medicine formulations that modulate neuro-immune crosstalk offer promising adjunctive treatments. A “predict-mechanism-intervene” paradigm is advocated to translate these advances into personalized management and improve long-term outcomes. |
| Publish Date |
2026-05-28 08:52 |
| Citation |
Gu JX, Liu CQ, Chen GX, Yao T, Sun ZX, Wang Y. Post-stroke depression update 2025: Mechanisms, prediction, and management. World J Psychiatry 2026; 16(6): 115996 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i6/115996.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i6.115996 |
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