| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Diagnostic efficacy and influencing factors of non-invasive liver fibrosis scores in chronic hepatitis B fibrosis: Cross-sectional study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Chun-Xia Wang, Pan Yan, Li-Juan Lan, Ben-Nan Zhao, Jun Kang, Mao-Quan Li and Da-Feng Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Project of Sichuan Provincial Medical Association |
S2024026 |
| the Sichuan Traditional Chinese Medicine Administration Research Program |
2024MS147 |
| the Open Fund of Sichuan Provincial Key Laboratory of Philosophy and Social Sciences for Intelligent Medical Care and Elderly Health Management |
ZHYYZKZD2401 |
|
| Corresponding Author |
Da-Feng Liu, Professor, The First Ward of Internal Medicine, Public Health Clinical Center of Chengdu, No. 377 Jingming Road, Jinjiang District, Chengdu 610066, Sichuan Province, China. ldf312@126.com |
| Key Words |
Chronic hepatitis B; Gamma-glutamyl transferase to platelet ratio; Fibrosis-4 index; Aspartate transaminase to platelet ratio index; Aspartate transaminase to alanine aminotransferase ratio; Child-Pugh classification; Nutritional risk |
| Core Tip |
This investigation was carried out in Southwest China, where the diagnostic efficacy of four non-invasive liver fibrosis scoring tools [aspartate transaminase to platelet ratio index, fibrosis-4 index (FIB-4), gamma-glutamyl transferase to platelet ratio (GPR), and aspartate aminotransferase to alanine aminotransferase ratio] was comprehensively assessed. The results indicated that GPR and FIB-4 achieved optimal diagnostic precision for detecting significant fibrosis and cirrhosis; notably, GPR demonstrated the strongest association with FibroScan-derived liver stiffness measurements. Furthermore, the study revealed that diagnostic performance is influenced by gender, nutritional status, and Child-Pugh grade. These findings indicate that incorporating GPR and FIB-4 into routine clinical assessment, along with patient-specific characteristics, can improve early screening for liver fibrosis in chronic hepatitis B. |
| Publish Date |
2026-05-26 03:52 |
| Citation |
Wang CX, Yan P, Lan LJ, Zhao BN, Kang J, Li MQ, Liu DF. Diagnostic efficacy and influencing factors of non-invasive liver fibrosis scores in chronic hepatitis B fibrosis: Cross-sectional study. World J Hepatol 2026; 18(5): 116008 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i5/116008.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i5.116008 |
