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4/15/2015 11:01:00 AM | Browse: 790 | Download: 836
Publication Name World Journal of Gastroenterology
Manuscript ID 11601
Country/Territory Australia
Received
2014-05-28 12:10
Peer-Review Started
2014-05-28 21:15
To Make the First Decision
2014-07-21 14:24
Return for Revision
2014-07-28 16:36
Revised
2014-08-06 08:52
Second Decision
2014-10-21 17:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-10-21 18:07
Articles in Press
2014-10-21 18:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-03-31 14:47
Publish the Manuscript Online
2015-04-15 11:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Microbiology
Manuscript Type Basic Study
Article Title Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery
Manuscript Source Unsolicited Manuscript
All Author List Susan Lapthorne, Julie E Bines, Fiona Fouhy, Nicole L Dellios, Guineva Wilson, Sarah L Thomas, Michelle Scurr, Catherine Stanton, Paul D Cotter and Prue M Pereira-Fantini
Funding Agency and Grant Number
Funding Agency Grant Number
Victorian Government’s Operational Infrastructure Support program
Science Foundation Ireland of Alimentary Pharmabiotic Centre SFI/12/RC/2273(in part)
Science Foundation Ireland of Alimentary Pharmabiotic Centre 12/RC/2273(in part)
PI grand to PCR 11/PI/1137
Irish Research Council EMBARK scholarship to FF
Corresponding author Prue M Pereira-Fantini, PhD, Head of Laboratory Research, Intestinal Failure and Clinical Nutrition group, Murdoch Childrens Research Institute, Royal Children’s Hospital, Flemington Road, Parkville Victoria 3052, Australia. prue.pereira@mcri.edu.au
Key Words Surgery; Intestinal; Microbiota; Dysbiosis; Inflammation; Surgery; Bacteria; Infant; Pediatric; Transection
Core Tip Early colonization of the infant gut is increasingly recognized as impacting on health due to the influence of resident microbes on nutritional, immunological and physiological functions. However, medical and surgical interventions required during infancy, including abdominal surgery, have the potential to modify the microbiome. Using 454-pyrosequencing technology we have described microbial dysbiosis within the Proteobacteria and Bacteriodetes phylum and increased gut inflammatory cytokines following transection surgery in a juvenile pig model. This is the first study examining minor surgery-associated changes in the gut microbiome and inflammation and provides new insights into potential long-term consequences of abdominal surgery in infancy.
Publish Date 2015-04-15 11:01
Citation Lapthorne S, Bines JE, Fouhy F, Dellios NL, Wilson G, Thomas SL, Scurr M, Stanton C, Cotter PD, Pereira-Fantini PM. Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery. World J Gastroenterol 2015; 21(14): 4150-4158
Url http://www.wjgnet.com/1007-9327/full/v21/i14/4150.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i14.4150
Full Article (PDF) WJG-21-4150.pdf
Full Article (Word) WJG-21-4150.doc
Manuscript File 11601-Review.docx
Answering Reviewers 11601-Answering reviewers.pdf
Copyright License Agreement 11601-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20140528110130.pdf
Peer-review Report 11601-Peer review.pdf
Scientific Misconduct Check 11601-CorssCheck.jpg
Scientific Editor Work List 11601-Scientific editor work list.pdf