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Articles Published Processes
4/15/2015 11:01:00 AM | Browse: 1545 | Download: 1938
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Received |
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2014-05-28 12:10 |
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Peer-Review Started |
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2014-05-28 21:15 |
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To Make the First Decision |
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2014-07-21 14:24 |
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Return for Revision |
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2014-07-28 16:36 |
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Revised |
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2014-08-06 08:52 |
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Second Decision |
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2014-10-21 17:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-21 18:07 |
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Articles in Press |
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2014-10-21 18:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-03-31 14:47 |
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Publish the Manuscript Online |
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2015-04-15 11:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Susan Lapthorne, Julie E Bines, Fiona Fouhy, Nicole L Dellios, Guineva Wilson, Sarah L Thomas, Michelle Scurr, Catherine Stanton, Paul D Cotter and Prue M Pereira-Fantini |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Victorian Government’s Operational Infrastructure Support program |
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| Science Foundation Ireland of Alimentary Pharmabiotic Centre |
SFI/12/RC/2273(in part) |
| Science Foundation Ireland of Alimentary Pharmabiotic Centre |
12/RC/2273(in part) |
| PI grand to PCR |
11/PI/1137 |
| Irish Research Council EMBARK scholarship |
to FF |
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| Corresponding Author |
Prue M Pereira-Fantini, PhD, Head of Laboratory Research, Intestinal Failure and Clinical Nutrition group, Murdoch Childrens Research Institute, Royal Children’s Hospital, Flemington Road, Parkville Victoria 3052, Australia. prue.pereira@mcri.edu.au |
| Key Words |
Surgery; Intestinal; Microbiota; Dysbiosis; Inflammation; Surgery; Bacteria; Infant; Pediatric; Transection |
| Core Tip |
Early colonization of the infant gut is increasingly recognized as impacting on health due to the influence of resident microbes on nutritional, immunological and physiological functions. However, medical and surgical interventions required during infancy, including abdominal surgery, have the potential to modify the microbiome. Using 454-pyrosequencing technology we have described microbial dysbiosis within the Proteobacteria and Bacteriodetes phylum and increased gut inflammatory cytokines following transection surgery in a juvenile pig model. This is the first study examining minor surgery-associated changes in the gut microbiome and inflammation and provides new insights into potential long-term consequences of abdominal surgery in infancy. |
| Publish Date |
2015-04-15 11:01 |
| Citation |
Lapthorne S, Bines JE, Fouhy F, Dellios NL, Wilson G, Thomas SL, Scurr M, Stanton C, Cotter PD, Pereira-Fantini PM. Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery. World J Gastroenterol 2015; 21(14): 4150-4158 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i14/4150.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i14.4150 |
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